{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:34:33Z","timestamp":1777890873496,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nowadays there is an increased interest in the role of aortic stiffness in the pathophysiology of heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>), as it is a major determinant of left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) performance. We aimed at assessing the predictive value of the aortic stiffness parameters, measured by echocardiography, in patients affected by nonischaemic dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>) regarding three end\u2010points: death, <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization, combined death or <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization in a long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 202 patients affected by nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> underwent an outpatient examination by echocardiography and blood pressure check at the brachial artery, in order to calculate aortic elastic properties (ie, compliance, distensibility, stiffness index, Peterson's elastic modulus, M\u2010mode strain). <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curves, Kaplan\u2010Meier curves and multivariable Cox regressions (correcting for age, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>), atrial fibrillation, cardiac resynchronization therapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>)) were run to assess the predictive ability of aortic elastic properties against the 3 end\u2010points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up was 9.83\u00a0\u00b1\u00a02.80\u00a0years. 24.8% of patients died, while 34.7% were rehospitalized for <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> cause and 44.6% experienced the combined end\u2010point. <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> did not correlate with aortic elastic properties. <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curves and Kaplan\u2010Meier curves were elaborated. Aortic stiffness did not predict death in our cohort. Otherwise, all aortic elastic properties predicted <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization and combined death or <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization, after correcting for age, <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>, atrial fibrillation, <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elastic properties of the ascending aorta measured by echocardiography in patients with nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> predict long\u2010term <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization and combined death or <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> rehospitalization, also after correcting for the confounding factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12950","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T18:39:44Z","timestamp":1526236784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic evaluation of the elastic properties of the ascending aorta in dilated cardiomyopathy"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-3454","authenticated-orcid":false,"given":"Edoardo","family":"Sciatti","sequence":"first","affiliation":[{"name":"Cardiology Unit University and ASST Spedali Civili Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Vizzardi","sequence":"additional","affiliation":[{"name":"Cardiology Unit University and ASST Spedali Civili Brescia 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