{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:39:53Z","timestamp":1787240393335,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Exchange in Endocrinology Expertise (3E) program of the European Union of Medical Specialists (UEMS), Section\u00a0and Board of Endocrinology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n To identify a serum prolactin (\n PRL<\/jats:styled-content>\n ) cut\u2010off value indicative of a\n PRL<\/jats:styled-content>\n \u2010producing adenoma in women with polycystic ovarian syndrome (\n PCOS<\/jats:styled-content>\n ) and hyperprolactinaemia and characterize such patients.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n In the present retrospective case\n \u2013<\/jats:bold>\n control study, the medical records of 528\n PCOS<\/jats:styled-content>\n women were reviewed. Pituitary magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) was performed in\n PCOS<\/jats:styled-content>\n patients with\n PRL<\/jats:styled-content>\n levels \u226594.0\u00a0ng\/mL and\/or symptoms suspicious of a pituitary adenoma (\n PA<\/jats:styled-content>\n ). Prolactinoma diagnosis was made in the presence of an\n MRI<\/jats:styled-content>\n \u2010identifiable\n PA<\/jats:styled-content>\n with biochemical and radiological response to dopamine agonists. Receiver operating characteristic (\n ROC<\/jats:styled-content>\n ) curve analysis was performed to determine a serum\n PRL<\/jats:styled-content>\n threshold that could identify hyperprolactinaemic\n PCOS<\/jats:styled-content>\n subjects with prolactinomas. Clinical, metabolic and endocrine parameters were also analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 528 patients with\n PCOS<\/jats:styled-content>\n , 60 (11.4%) had elevated\n PRL<\/jats:styled-content>\n levels. Of 44 (73.3%) patients who had pituitary imaging, 19 had\n PA<\/jats:styled-content>\n s, 18 normal\n MRI<\/jats:styled-content>\n and 7 other abnormalities. Patients harbouring prolactinomas had significantly higher\n PRL<\/jats:styled-content>\n levels compared to patients without adenomas (median\n PRL<\/jats:styled-content>\n 95.4 vs 49.2\u00a0ng\/mL,\n P<\/jats:italic>\n \u00a0<\u00a0.0001). A\n PRL<\/jats:styled-content>\n threshold of 85.2\u00a0ng\/mL could distinguish patients with prolactinomas with 77% sensitivity and 100% specificity [Area Under the curve (\n AUC<\/jats:styled-content>\n ) (95%) 0.91(0.8\u20101.018),\n P<\/jats:italic>\n \u00a0=\u00a0.0001].\n PCOS<\/jats:styled-content>\n women with prolactinomas were younger and had lower\n LH<\/jats:styled-content>\n levels compared to women without prolactinomas.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In women with\n PCOS<\/jats:styled-content>\n ,\n PRL<\/jats:styled-content>\n levels exceeding 85.2\u00a0ng\/mL are highly suggestive of a prolactinoma warranting pituitary imaging. Pituitary\n MRI<\/jats:styled-content>\n could also be considered in young\n PCOS<\/jats:styled-content>\n patients with milder\n PRL<\/jats:styled-content>\n elevation and low\n LH<\/jats:styled-content>\n levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eci.12961","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T21:10:02Z","timestamp":1527628202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The value of prolactin in predicting prolactin\u03bfma in hyperprolactinaemic polycystic ovarian syndrome"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-8734","authenticated-orcid":false,"given":"Eleni Magdalini","family":"Kyritsi","sequence":"first","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM) University Hospitals Coventry and Warwickshire NHS Trust Coventry 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