{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:15:08Z","timestamp":1791890108994,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin\u2010like growth factor (IGF\u20101) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective, cross\u2010sectional study conducted after approval by Institutional authorities. Anthropometric data, disease\u2010related factors, biochemical and clinical indices of inflammation and endocrine parameters were recorded and considered as explanatory covariates. A structural equation\u00a0model analysis was utilized. Somatic height was the outcome of interest, and possible associations of explanatory covariates directly or through the mediation effect of IGF\u20101 were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systemic inflammation, as expressed by high\u2010sensitivity intereukin\u20106 (IL\u20106), and nutritional status described by body mass index (BMI) were the pathways that significantly affected stature through the mediation effect of IGF\u20101. Cortisol showed a direct, positive and independent of IGF\u20101 association with height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin\u2010like growth factor\u20101 is a key player in the process that results in impaired linear growth. Malnutrition and systemic inflammation have a restrictive action on growth by reducing circulating IGF\u20101. The positive relation of serum cortisol to height could correspond to suppressed pituitary\u2010adrenal axis due to long\u2010term use of glucocorticoids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12969","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T14:50:20Z","timestamp":1528815020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Body height in paediatric inflammatory bowel diseases: A\u00a0structural equation\u00a0model analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-3486","authenticated-orcid":false,"given":"Giorgos","family":"Chouliaras","sequence":"first","affiliation":[{"name":"First Department of Pediatrics \u201cAghia Sophia\u201d Children's Hospital University of Athens Athens 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