{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:07:11Z","timestamp":1774336031284,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The aim of this study was to compare the prevalence of lumbar spondylolisthesis (SPL<\/jats:styled-content>) in patients suffering from low back pain (LBP<\/jats:styled-content>) with or without rheumatoid arthritis (RA<\/jats:styled-content>) and to identify potential factors associated with SPL<\/jats:styled-content> in patients with RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a case\u2010control study. Cases and control patients had chronic LBP<\/jats:styled-content> (more than 4\u00a0weeks). Patient with RA<\/jats:styled-content> fulfilled the 2010 ACR<\/jats:styled-content>\/EULAR<\/jats:styled-content> criteria. The main outcome was the presence of lumbar SPL<\/jats:styled-content> on lumbar X\u2010ray. The prevalence of SPL<\/jats:styled-content> between RA<\/jats:styled-content> and control patients was compared using chi\u2010squared test. Potential factors associated with SPL<\/jats:styled-content> in patients with RA<\/jats:styled-content> were investigated by univariate and multivariate analysis, estimating odds ratios (OR<\/jats:styled-content>s) and 95% confidence intervals (95% CI<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 67 cases and 83 controls were included. Median [interquartile range] age of patients with RA<\/jats:styled-content> was 60.0\u00a0years [51.0\u201072.0]; 80.6% were females; and 92.5% and 83.6% were positive for anti\u2010citrullinated protein antibodies (ACPA<\/jats:styled-content>s) or rheumatoid factor, respectively. Mean RA<\/jats:styled-content> disease duration was 11.2\u00a0\u00b1\u00a08.7\u00a0years. SPL<\/jats:styled-content> was more frequent in patients with RA<\/jats:styled-content> than controls (41.8% versus 18.1%, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001). Adjusted to gender, RA<\/jats:styled-content> was associated with increased prevalence of SPL<\/jats:styled-content> (OR<\/jats:styled-content> 3.15 [95% CI<\/jats:styled-content> 1.48\u20106.70], P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003). Among patients with RA<\/jats:styled-content>, SPL<\/jats:styled-content> was mainly Grade 1 (85.7%). Multivariate analysis revealed SPL<\/jats:styled-content> is associated with increased age in patients with RA<\/jats:styled-content> (OR<\/jats:styled-content> 1.06 [1.02\u20101.11], P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.004).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In a population of patients with chronic LBP<\/jats:styled-content>, the prevalence of lumbar SPL<\/jats:styled-content> was higher with than without RA<\/jats:styled-content>. SPL<\/jats:styled-content> might be explained by synovitis of lumbar facet joints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12991","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T09:09:32Z","timestamp":1530263372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased rate of lumbar spondylolisthesis in rheumatoid arthritis: A case\u2010control study"],"prefix":"10.1111","volume":"48","author":[{"given":"Benjamin","family":"Hagege","sequence":"first","affiliation":[{"name":"AP\u2010HP Service de Rhumatologie H\u00f4pital Bichat\u2010Claude Bernard Paris France"},{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Tubach","sequence":"additional","affiliation":[{"name":"AP\u2010HP D\u00e9partement de Biostatistiques, Sant\u00e9 Publique et Informatique 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