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In most patients, leukaemic cells can be kept under control using\n                    <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>\n                    1\u2010targeting drugs. However, many patients relapse which remains a clinical challenge. In particular, patients with advanced (accelerated or blast phase)\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    have a poor prognosis. So far, little is known about molecular and cellular interactions and features that contribute to disease progression and drug resistance in\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    . One key prognostic factor at diagnosis is marked basophilia. However, although basophils are well\u2010known multifunctional effector cells, their impact in\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    remains uncertain. In this article, we discuss the potential role of basophils as active contributors to disease evolution and progression in\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    . In particular, basophils serve as a unique source of inflammatory, angiogenic and fibrogenic molecules, such as vascular endothelial growth factor or hepatocyte growth factor. In addition, basophils provide vasoactive substances, like histamine as well as the cytokine\u2010degrading enzyme dipeptidyl\u2010peptidase\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    which may promote stem cell mobilization and the extramedullary spread of stem and progenitor cells. Finally, basophils may produce autocrine growth factors for myeloid cells. Understanding the role of basophils in\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    evolution and progression may support the development of more effective treatment concepts.\n                  <\/jats:p>","DOI":"10.1111\/eci.13000","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T14:47:35Z","timestamp":1531925255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The underestimated role of basophils in Ph\n                    <sup>+<\/sup>\n                    chronic myeloid leukaemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5095","authenticated-orcid":false,"given":"Peter","family":"Valent","sequence":"first","affiliation":[{"name":"Division of Hematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna 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