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Patients were clinically followed up for a median period of 54\u00a0weeks. Serum circulating levels of C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 and \u20102, matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20109 and \u20108, myeloperoxidase (<jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>) and neutrophil elastase (<jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>) were assessed by<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>at enrolment and at the end of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage (%)<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102 reduction from baseline to end of treatment was independently associated with<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>remission at the end of treatment and follow\u2010up as well.<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>curve analysis further confirmed the good prognostic accuracy of %<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102 reduction over the treatment period. Conversely, no other change in inflammatory molecule concentrations was able to predict short\u2010 or long\u2010term<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicates<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102 reduction during<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>treatment with monoclonal anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 antibodies as a potential prognostic parameter of short and long term remission. To understand if<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102 is an innocent biomarker or an active pathophysiological factor in<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>remains to be clarified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13002","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T12:50:20Z","timestamp":1531745420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reduction in<scp>TIMP<\/scp>\u20102 serum levels predicts remission of inflammatory bowel diseases"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4078","authenticated-orcid":false,"given":"Federico","family":"Carbone","sequence":"first","affiliation":[{"name":"First Clinic of Internal Medicine Department of Internal Medicine University of Genoa Genoa 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