{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:41:58Z","timestamp":1784882518393,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon\u2010like peptide\u20101 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 139 patients who were referred because of suboptimal glycaemic control were randomly assigned to liraglutide 0.9\u00a0mg\/d (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>45), sitagliptin 50\u00a0mg\/d, (n\u00a0=\u00a049) or linagliptin 5\u00a0mg\/d (n\u00a0=\u00a045) at enrolment and were evaluated. Blood glucose, glycosylated haemoglobin and serum creatinine were assayed every 3\u00a0months for 48\u00a0months. Echocardiography was performed every 12\u00a0months for 48\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with baseline, fasting glucose, postprandial glucose, and systolic and diastolic pressure, but not estimated glomerular filtration rate, significantly decreased in all three groups. Albuminuria decreased from 24 to 48\u00a0months with liraglutide, but only from 24 to 30\u00a0months with sitagliptin and linagliptin. Diastolic function, assessed by E\/e\u2032 or left atrial dimension improved only with liraglutide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liraglutide was effective for glucose and blood pressure control, reduced albuminuria and improved diastolic function. Diastolic function was not improved by sitagliptin and linagliptin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13007","type":"journal-article","created":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T06:23:00Z","timestamp":1532758980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Liraglutide relieves cardiac dilated function than <scp>DPP<\/scp>\u20104 inhibitors"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-600X","authenticated-orcid":false,"given":"Takeyuki","family":"Hiramatsu","sequence":"first","affiliation":[{"name":"Department of Nephrology Aichi Welfare Cooperative Agricultural Federation Konan Kosei Hospital Konan\u2010city Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aichi Welfare Cooperative Agricultural Federation Konan Kosei Hospital Konan\u2010city Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsuna","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aichi Welfare Cooperative Agricultural Federation Konan Kosei Hospital Konan\u2010city Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aichi Welfare Cooperative Agricultural Federation Konan Kosei Hospital Konan\u2010city Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aichi Welfare Cooperative Agricultural Federation Konan Kosei Hospital Konan\u2010city Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Nephrology 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