{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:56:13Z","timestamp":1781726173849,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005187","name":"National and Kapodistrian University of Athens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood obesity represents a major health problem of our century. The benefits of natural products, such as honey, in the management of obesity have gained renewed interest. In this study, we investigated the effect of honey on glucose and insulin concentrations in obese prepubertal girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty healthy obese girls aged 10.55 (\u00b1<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>:0.34) years with a mean body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) above the 97th centile for age (28.58\u00a0\u00b1\u00a01.40\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:styled-content style=\"fixed-case\">BMI <\/jats:styled-content><jats:italic>z<\/jats:italic>\u2010score 2.96) underwent a standard oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) followed by an oral honey tolerance test (<jats:styled-content style=\"fixed-case\">OHTT<\/jats:styled-content>) 2\u00a0weeks later. Both solutions contained 75\u00a0g of glucose. Subsequently, subjects were randomized to receive either 15\u00a0g of honey or 15\u00a0g of marmalade daily, while both groups complied with dietetic instructions. Six months later all subjects were re\u2010evaluated with an <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> and an <jats:styled-content style=\"fixed-case\">OHTT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the study, all subjects demonstrated a significant reduction in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (27.57\u00a0\u00b1\u00a01.40, <jats:italic>z<\/jats:italic>\u2010score: 2.54 vs 28.58\u00a0\u00b1\u00a01.40\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>z<\/jats:italic>\u2010score: 2.96, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), however, there were no significant differences in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and all parameters tested between the group that received honey and the control group. The areas under the concentration\u2013time curve for glucose and insulin for the entire population were significantly lower following ingestion of honey than glucose solution (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) both at the beginning and at the end of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicate that honey does not have an effect on stimulated plasma glucose and serum insulin concentrations compared with the standard glucose solution in obese prepubertal girls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13042","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T15:29:08Z","timestamp":1540740548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of honey on glucose and insulin concentrations in obese girls"],"prefix":"10.1111","volume":"49","author":[{"given":"Ioanna","family":"Farakla","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes First Department of Pediatrics, National and Kapodistrian University of Athens Medical School \u2018Aghia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Koui","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes First Department of Pediatrics, National and Kapodistrian University of Athens Medical School \u2018Aghia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Arditi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes First Department of Pediatrics, National and Kapodistrian University of Athens Medical School \u2018Aghia Sophia\u2019 Children's 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