{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:03:40Z","timestamp":1761663820258,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The outcome of patients with chronic hepatitis C virus infection (HCV) and advanced, compensated liver disease after sustained virological response (SVR) to direct\u2010acting antivirals (DAAs) has not yet been completely depicted. We aimed to assess the clinical, biochemical and instrumental outcome of patients with advanced, compensated chronic HCV\u2010related liver disease with DAA\u2010induced SVR to DAAs and who had at least 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty\u2010two patients with cirrhosis (n\u00a0=\u00a027) and fibrosis stage F3 (n\u00a0=\u00a025) followed up for a median of 60\u00a0weeks after successful DAA treatment were included. Laboratory work\u2010up, including APRI and FIB\u20104 scores, liver transient elastography and measurement of the spleen bi\u2010polar diameter were carried out before treatment and at the end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver stiffness decreased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) from a median baseline of 15.2\u00a0kPa (12.0\u201020.0) to 9.3\u00a0kPa (7.5\u201012.0) at follow\u2010up. A liver stiffness value suggestive of the presence (ie, \u226521.0\u00a0kPa) of clinically significant portal hypertension was found in 13 patients (25.0%) at baseline and in seven patients (13.5%) at follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037). Both APRI (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and FIB\u20104 score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) progressively decreased, while platelet count increased (143\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L [117\u2010176] to 153\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L [139\u2010186], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), and spleen bi\u2010polar diameter decreased (120\u00a0mm [112\u2010123] to 110\u00a0mm [102\u2010116], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009) from baseline to the end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients advanced, compensated chronic liver disease, liver stiffness significantly improves in the long\u2010term after SVR, and this improvement is accompanied by an amelioration of indirect indices of liver fibrosis and function, and by a decrease in parameters of portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13056","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T08:35:45Z","timestamp":1543221345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Improvement in hepatitis C virus patients with advanced, compensated liver disease after sustained virological response to direct acting antivirals"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-837X","authenticated-orcid":false,"given":"Edoardo G.","family":"Giannini","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, Ospedale Policlinico San Martino\u2010IRCCS per l\u2019Oncologia University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Crespi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of 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