{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:51:43Z","timestamp":1792601503957,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taipei Medical University and Shuang-Ho Hospital","award":["105TMU-SHH-24"],"award-info":[{"award-number":["105TMU-SHH-24"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dysregulation of the type 1 interferon (IFN)\u2010related signalling pathway predisposes one to autoimmune diseases. Possible associations of single\u2010nucleotide polymorphisms (SNPs) of secreted phosphoprotein 1 (SPP1) and B lymphocyte kinase (BLK) of the type 1 IFN\u2010related signalling pathway with autoimmune thyroid disease (AITD) in an ethnic Chinese (ie Taiwanese) population were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 83 Hashimoto's thyroiditis (HT) patients, 319 Graves\u2019 disease (GD) patients and 369 controls were enrolled. Genotypes of the two SNPs (rs1126772 and rs1126616) of SPP1 and two SNPs (rs13277113 and rs2736340) of BLK were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037, odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.62\u20100.99) and HT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002, OR = 0.54, 95% CI = 0.36\u20100.81), compared to the controls. At the same time, lower frequencies of the C allele of rs2736340 of BLK in GD (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025, OR = 0.76, 95% CI = 0.60\u20100.97) and HT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, OR = 0.53, 95% CI = 0.35\u20100.81) than the controls were also observed. There were significantly higher AT haplotype frequencies of rs1327713 and rs2736340 in GD and HT patients than in the controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025, OR = 1.31, 95% CI = 1.03\u20101.67, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, OR = 1.89, 95% CI = 1.24\u20102.87, respectively). Moreover, the anti\u2010microsomal antibody titre was associated with rs2736340.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population. Our results suggest the BLK may participate in the pathogenesis of GD, HT and AITD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13065","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T19:59:41Z","timestamp":1545940781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of secreted phosphoprotein 1 and B lymphocyte kinase gene polymorphisms with autoimmune thyroid disease"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-6630","authenticated-orcid":false,"given":"Chao\u2010Wen","family":"Cheng","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Traditional Herb Medicine Research Center Taipei Medical University Hospital, Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-7927","authenticated-orcid":false,"given":"Shun\u2010Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Medical Research Shuang\u2010Ho Hospital, Taipei Medical University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Shuang\u2010Ho Hospital, Taipei Medical University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Chin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Shuang\u2010Ho Hospital, Taipei Medical University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam\u2010Tsun","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-8249","authenticated-orcid":false,"given":"Jiunn\u2010Diann","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine Shuang Ho Hospital, Taipei Medical University New Taipei City Taiwan"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine 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