{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:57:34Z","timestamp":1777100254089,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fungal infections are still a relevant challenge for clinicians involved in the cure of patients with cancer. We retrospectively reviewed charts of hospitalized patients with haematological malignancies (HMs), in which a documented fungaemia was diagnosed between January 2011 and December 2015 at 28 adult and 6 paediatric Italian Hematology Departments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the study period, we recorded 215 fungal bloodstream infections (BSI). Microbiological analyses documented that BSI was due to moulds in 17 patients (8%) and yeasts in 198 patients (92%), being <jats:italic>Candida spp<\/jats:italic> identified in 174 patients (81%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mortality rates were 70% and 39% for mould and yeast infections, respectively. Infection was the main cause of death in 53% of the mould and 18% of the yeast groups. At the multivariate analysis, ECOG\u00a0\u2265\u00a02 and septic shock were significantly associated with increased mortality, and removal of central venous catheter (CVC) survival was found to be protective. When considering patients with candidemia only, ECOG\u00a0\u2265\u00a02 and removal of CVC were statistically associated with overall mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although candidemia represents a group of BSI with a good prognosis, its risk factors largely overlap with those identified for all fungaemias, even though the candidemia\u2010related mortality is lower when compared to other fungal BSI. Management of fungal BSI is still a complex issue, in which both patients and disease characteristics should be focused to address a personalized approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13083","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T14:52:41Z","timestamp":1549637561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Fungaemia in haematological malignancies: SEIFEM\u20102015 survey"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-2338","authenticated-orcid":false,"given":"Marianna","family":"Criscuolo","sequence":"first","affiliation":[{"name":"Dipartimento Scienze Radiologiche Radioterapiche ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Candoni","sequence":"additional","affiliation":[{"name":"Clinica Ematologica, Centro Trapianti e Terapie Cellulari Azienda Sanitaria Universitaria Integrata di Udine Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Nosari","sequence":"additional","affiliation":[{"name":"Hematology ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Veggia","sequence":"additional","affiliation":[{"name":"Department of Hematology Azienda Ospedaliera San Giovanni Addolorata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Verga","sequence":"additional","affiliation":[{"name":"Ematologia adulti e CTA ASST Monza Universit\u00e0 Milano Bicocca, Ospedale San Gerardo Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fracchiolla","sequence":"additional","affiliation":[{"name":"Hematology Fondazione IRCCS Ca\u2019 Granda\u2010Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Vianelli","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Policlinico S. Orsola \u2013 Malpighi Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[{"name":"Hematology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Science AOU\u2010Federico II Napoli Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Tumbarello","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fondazione Policlinico A. Gemelli IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Aversa","sequence":"additional","affiliation":[{"name":"Hematology University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"Department of Hematology Ospedale Le Molinette Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Radiologiche Radioterapiche ed Ematologiche Fondazione Policlinico A. 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