{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:18:02Z","timestamp":1790965082374,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007517","name":"Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado","doi-asserted-by":"publisher","award":["E015"],"award-info":[{"award-number":["E015"]}],"id":[{"id":"10.13039\/501100007517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2015-1-262335 FOSSIS"],"award-info":[{"award-number":["SALUD-2015-1-262335 FOSSIS"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atherosclerosis represents a cardiovascular risk. Chronic inflammation is a key factor for atherogenic progression. Neutrophil\u2010to\u2010lymphocyte ratio (NLR) has been proposed as a novel biomarker for cardiovascular risks. We aimed to explore whether NLR was related to surrogate pro\u2010atherogenic promoters driving atherogenic progression, as measured by carotid intima\u2010media thickness (CIMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Thirty\u2010one patients with obesity candidates for bariatric surgery were recruited from Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City. The results are part of the \u201cCROP\u201d study (NCT03561987). NLR was calculated from routine complete blood count, and its relation with plasma pro\u2010inflammatory mediators (hsCRP, TNF\u2010\u03b1 and IL\u20101\u03b2), adipokines (adiponectin and leptin), adiposity markers (visceral adipose tissue [VAT] determined from CT scan image and VAT individual adipocyte area at histological sample) and CIMT were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neutrophil\u2010to\u2010lymphocyte ratio correlated with hsCRP (Spearman's <jats:italic>r<\/jats:italic>\u00a0=\u00a00.70 [95% CI 0.46 to 0.85], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), TNF\u2010\u03b1 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.69 [0.44 to 0.84], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and adiponectin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.69 [\u22120.84 to \u22120.45], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.03), as well as with VAT individual adipocyte area (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.64 [0.37 to 0.81], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and with VAT area (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.43; [0.07 to 0.68], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Leptin and adiponectin showed further independent association with higher NLR (multivariate regression analysis OR 7.9 [95% CI 1.1 to 56.2] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03 and 0.1 [0.01 to 1.0] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05, respectively). Moreover, NLR distribution significantly varied between subgroups divided according to progressive CIMT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05); whereas adiponectin and VAT adipocyte area associated with CIMT\u00a0&gt;\u00a00.9\u00a0mm (univariate analysis OR 0.1 [0.01 to 1.0] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05 and 13.1 [1.4 to 126.3] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neutrophil\u2010to\u2010lymphocyte ratio was related to pro\u2010inflammatory, adiposity biomarkers and progressive subclinical atherogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13085","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T09:28:41Z","timestamp":1549877321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Neutrophil\u2010to\u2010lymphocyte ratio and its relation with pro\u2010inflammatory mediators, visceral adiposity and carotid intima\u2010media thickness in population with obesity"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-5658","authenticated-orcid":false,"given":"Juan Antonio","family":"Su\u00e1rez\u2010Cuenca","sequence":"first","affiliation":[{"name":"Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d Mexico City Mexico"},{"name":"Internal Medicine Department Hospital General de Xoco, SEDESA Mexico City Mexico"},{"name":"Internal Medicine Department Hospital General de Zona No. 58, IMSS State of Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atzin S.","family":"Ru\u00edz\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana A.","family":"Mendoza\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela A.","family":"Dom\u00ednguez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Hern\u00e1ndez\u2010Patricio","sequence":"additional","affiliation":[{"name":"Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research Centro M\u00e9dico Nacional \u201c20 de 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