{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:09:05Z","timestamp":1769087345580,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["F2-2013-602114"],"award-info":[{"award-number":["F2-2013-602114"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultrasound evaluation of carotid intima\u2010media thickness (cIMT) has been extensively used for potentially improving cardiovascular (CV) risk stratification in several patients\u2019 categories. Subjects with systemic lupus erythematosus (SLE) have been investigated by both imaging and molecular biomarker approaches with contrasting results. Here, we focused on the role of osteopontin (OPN) as biomarker of subclinical atherosclerosis associated with SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eighty females (age 18\u201065\u00a0years) affected by SLE and eighty age\u2010matched healthy female controls without a clinical history of CV disease underwent ultrasound evaluation of cIMT and blood sample assay of high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and OPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Healthy controls and SLE patients significantly differed for CV risk factors (ie, waist circumference, hypertension and dyslipidaemia) and the inflammatory status. Noteworthy, an opposite association between cIMT and OPN was observed in the two study groups. Whereas OPN was positively associated with mean cIMT (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.364; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) in SLE patients, a negative correlation was found in healthy controls. Furthermore, in SLE patients increased circulating levels of OPN were associated with the use of hydroxychloroquine and the positivity for the anti\u2010dsDNA autoantibodies. At linear regression analysis, only OPN remained independently associated with cIMT also after adjustment for age, smoking pack\u2010year, Heart SCORE, disease length and steroid therapy length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that serum OPN levels were strongly associated with subclinical atherosclerosis in patients with LES and it might be a useful CV biomarker that requires additional validation in larger trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13089","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T05:05:58Z","timestamp":1550207158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum osteopontin negatively impacts on intima\u2010media thickness in patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4078","authenticated-orcid":false,"given":"Federico","family":"Carbone","sequence":"first","affiliation":[{"name":"First Clinic of Internal Medicine, Department of Internal Medicine University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Dallegri","sequence":"additional","affiliation":[{"name":"First Clinic of Internal Medicine, Department of Internal Medicine University of Genoa Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genoa \u2013 Italian Cardiovascolar Network Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-8729","authenticated-orcid":false,"given":"Fabrizio","family":"Montecucco","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino Genoa \u2013 Italian Cardiovascolar Network Genoa Italy"},{"name":"First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR) University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Poggi","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Angiogenesis Unit Policlinico San Martino Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio Mariano","family":"Nobili","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino Genoa \u2013 Italian Cardiovascolar Network Genoa Italy"},{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI) University of Genoa, Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cacciapaglia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organs Transplantation (DETO) University of Bari Bari 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