{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:10Z","timestamp":1753878730455,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001808","name":"Kommission f\u00fcr Technologie und Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The phenomenon of exercise\u2010induced left ventricular dysfunction (LVD) is incompletely understood. Better understanding of its prevalence and determinants might help to address the current potential oversimplification of the relation between physical activity and cardiac health in patients with coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively assessed the prevalence and determinants of exercise\u2010induced LVD in patients with stable CAD and normal LV function at rest undergoing bicycle rest\/stress myocardial perfusion imaging single\u2010photon emission computed tomography (MPI\u2010SPECT). Exercise\u2010induced LVD was defined as a relevant (5% or more) drop in left ventricular ejection fraction after maximal exercise. High\u2010sensitivity cardiac troponin I\/T (Hs\u2010cTnI\/T) and N\u2010terminal probrain natriuretic peptide (NT\u2010proBNP) concentrations were measured before exercise to quantify cardiomyocyte injury and hemodynamic cardiac stress, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 317 patients, exercise\u2010induced LVD was present in 83 (26%) patients. Exercise\u2010induced LVD was associated with the extent of exercise\u2010inducible myocardial ischaemia as well as transient ischaemic dilatation. Still, 43% of patients developing exercise\u2010induced LVD did not have functionally relevant CAD. Neither baseline characteristics, nor the quantification of the extent of cardiomyocyte injury and hemodynamic cardiac stress using hs\u2010cTnI\/T and NT\u2010proBNP concentrations, respectively, allowed predicting exercise\u2010induced LVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One out of four patients with stable CAD develops exercise\u2010induced LVD after bicycle exercise test. While the extent of exercise\u2010inducible myocardial ischaemia is a predictor, other still unrecognized mechanisms also seem to play a major role, as nearly half of all patients with exercise\u2010induced LVD do not have functionally relevant CAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13112","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T17:05:10Z","timestamp":1553879110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and determinants of exercise\u2010induced left ventricular dysfunction in patients with coronary artery disease"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-0663","authenticated-orcid":false,"given":"Ursina","family":"Honegger","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Puelacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"Division of Internal Medicine, University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Schaerli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"Division of Internal Medicine, University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg University Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper","family":"Boeddinghaus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"Division of Internal Medicine, University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nestelberger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"du Fay de Lavallaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Wussler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otmar","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raban","family":"Jeger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Wild","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Schmidt\u2010Trucks\u00e4ss","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise, and Health University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"10","article-title":"Exercise\u2010based rehabilitation for coronary heart disease (Review)","author":"Anderson L","year":"2016","journal-title":"Cochrane Database Syst. Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151788.08740.5C"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Update I Physical inactivity as a risk factor for coronary heart disease : a WHO and International Society and Federation of Cardiology position statement*","volume":"72","author":"Bijnen F","year":"1994","journal-title":"Bull. World Health Organ"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.4.857"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw334"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000366"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.123117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr397"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022924"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"103","article-title":"Left ventricular systolic function is sensitive to cycle\u2010length irregularity in patients with atrial fibrillation and systolic dysfunction","volume":"28","author":"Chia\u2010Pin L","year":"2012","journal-title":"Acta Cardiol Sin"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht296"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-99"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00388-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0661-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03170707"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev095"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"e_1_2_8_22_1","first-page":"176","article-title":"Effect of perfusion pattern and imaging sequence on gated perfusion SPECT evaluation of myocardial stunning","volume":"46","author":"Manrique A","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2006.10.019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-1127-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq509"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs154"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.05.020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.01.009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12535"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.277210"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.286971"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011204"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.11.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1309\/LR7FC0LUGLHT8X6J"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0540"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.134460"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.08.016"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.11.010"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.546"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.13112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T22:46:59Z","timestamp":1692658019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/eci.13112"],"URL":"https:\/\/doi.org\/10.1111\/eci.13112","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"type":"print","value":"0014-2972"},{"type":"electronic","value":"1365-2362"}],"subject":[],"published":{"date-parts":[[2019,5,21]]},"assertion":[{"value":"2018-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13112"}}