{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:05:46Z","timestamp":1787166346113,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Disturbances in adipose tissue glucose uptake may play a role in the pathogenesis of type 2 diabetes, yet its examination by 2\u2010deoxy\u20102\u2010[\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG) PET\/CT is challenged by relatively low uptake kinetics. We tested the hypothesis that performing [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT during a hypoglycaemic clamp would improve adipose tissue tracer uptake to allow specific comparison of adipose tissue glucose handling between people with or without type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      We enrolled participants with or without diabetes who were at least overweight, to undergo a hyperinsulinaemic hypoglycaemic clamp or a hyperinsulinaemic euglycaemic clamp (n\u00a0=\u00a05 per group). Tracer uptake was quantified using [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypoglycaemic clamping increased [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake in visceral adipose tissue of healthy participants (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002). During hypoglycaemia, glucose uptake in visceral adipose tissue of type 2 diabetic participants was lower as compared to healthy participants (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0005). No significant differences were observed in skeletal muscle, liver or pancreas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present findings indicate that [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT during a hypoglycaemic clamp provides a promising new research tool to evaluate adipose tissue glucose metabolism. Using this method, we observed a specific impairment in visceral adipose tissue [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake in type 2 diabetes, suggesting a previously underestimated role for adipose tissue glucose handling in type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13120","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T06:20:13Z","timestamp":1555654813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["PET imaging during hypoglycaemia to study adipose tissue metabolism"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-1803","authenticated-orcid":false,"given":"Marti","family":"Boss","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne M. 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