{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:08:23Z","timestamp":1792613303707,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","award":["This study was supported by an unrestricted grant"],"award-info":[{"award-number":["This study was supported by an unrestricted grant"]}],"id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>GDF\u201015 is an established cardiovascular risk marker but is equally implicated in tumour biology. Elevated levels of GDF\u201015 have indeed been observed in distinct tumour entities. This study aimed to explore the relation of GDF\u201015 to other cardiac biomarkers and the general association of GDF\u201015 on prognosis in an unselected cohort of treatment\u2010na\u00efve cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 555 consecutive patients at time of diagnosis of malignant disease prior receiving anticancer therapy. Plasma GDF\u201015 concentrations were determined alongside other cardiac and routine laboratory markers. All\u2010cause mortality was defined as primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GDF\u201015 levels were 338\u00a0ng\/L (IQR:205\u2010534) for the total cohort, and values were comparable for different tumour entities except breast cancer. Metastatic disease was characterized by higher plasma GDF\u201015 [435\u00a0ng\/L (IQR:279\u2010614) vs 266\u00a0ng\/L (IQR:175\u2010427), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001]. GDF\u201015 correlated positively with inflammatory status reflected by CRP, SAA and IL\u20106 [<jats:italic>r<\/jats:italic>\u00a0=\u00a0.31, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.23, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0.14, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002] and cardiac biomarkers as NT\u2010proBNP, hsTnT, MR\u2010proADM and CT\u2010proET\u20101 [<jats:italic>r<\/jats:italic>\u00a0=\u00a0.46; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.46; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.59 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0.50; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 for all]. GDF\u201015 was significantly associated with all\u2010cause mortality after multivariate adjustment [adj.HR for ln(GDF\u201015) 1.78, 95%CI:1.47\u20102.16, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001]. There was a significant interaction between solid and haematological malignancies with loss of association of GDF\u201015 with outcome in myelodysplastic and myeloproliferative disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated plasma GDF\u201015 is associated with progressing disease severity and poor prognosis in solid tumours of treatment\u2010na\u00efve cancer patients. GDF\u201015 increase is accompanied by worsening systemic inflammation and a subclinical functional impairment of different organs including the heart. GDF\u201015 represents a promising target for our pathophysiologic understanding in cardio\u2010oncology linking conditions of both cardiac and neoplastic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13168","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T05:59:14Z","timestamp":1567058354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["GDF\u201015 in solid vs non\u2010solid treatment\u2010na\u00efve malignancies"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-7759","authenticated-orcid":false,"given":"Henrike","family":"Arfsten","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Division of Cardiology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of 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