{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:25:08Z","timestamp":1772810708750,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) is a frequent finding in HFpEF. However, its association with invasive haemodynamics, imaging parameters and outcome in HFpEF is not well established. Furthermore, the relevance of AF subtype with regard to outcome is unclear. This study sought to investigate the prognostic impact of paroxysmal and persistent AF in a well\u2010defined heart failure with preserved ejection fraction (HFpEF) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Between 2010 and 2016, 254 HFpEF patients were prospectively enrolled. All patients underwent echocardiography as well as left and right heart catheterization. Patients without contraindications underwent CMR including T1 mapping. Follow\u2010up and outcome data were collected. Patients with significant coronary artery disease were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 153 patients (60%) suffered from AF, 119 (47%) had persistent and 34 (13%) had paroxysmal AF. By multiple logistic regression analysis, persistent AF was independently associated with NT\u2010proBNP (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), NYHA functional class (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.040), left and right atrial size (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.022 and &lt;.001, respectively), cardiac output (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) and COPD (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.034). After a median follow\u2010up of 23\u00a0months (interquartile range 5\u201048), 92 patients (36%) reached the primary end point defined as hospitalization for heart failure or cardiovascular death. By multivariate Cox regression analysis, only persistent AF (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and six\u2010minute walk distance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) were independently associated with the primary end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sixty percent of our HFpEF patients suffered from AF. Persistent but not paroxysmal AF was strongly associated with event\u2010free survival and was independently related to NYHA functional class, serum NT\u2010proBNP, atrial size, cardiac ouput and presence of COPD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13184","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T10:04:10Z","timestamp":1573898650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Persistent atrial fibrillation in heart failure with preserved ejection fraction: Prognostic relevance and association with clinical, imaging and invasive haemodynamic parameters"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-9716","authenticated-orcid":false,"given":"Robert","family":"Sch\u00f6nbauer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Division of Cardiology Medical University of Vienna Vienna 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