{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:38:42Z","timestamp":1790948322774,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/01959"],"award-info":[{"award-number":["PI15\/01959"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01156"],"award-info":[{"award-number":["PI16\/01156"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Following the SEPSIS\u20103 consensus, detection of organ failure as assessed by the SOFA (Sequential Organ Failure Assessment) score, is mandatory to detect sepsis. Calculating SOFA outside of the Intensive Care Unit (ICU) is challenging. The alternative in this scenario, the quick SOFA, is very specific but less sensible. Biomarkers could help to detect the presence of organ failure secondary to infection either in ICU and non\u2010ICU settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We evaluated the ability of four biomarkers (C\u2010Reactive protein (CRP), lactate, mid\u2010regional proadrenomedullin (MR\u2010proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariate analysis, MR\u2010proADM was an independent predictor of five different failures (respiratory, coagulation, cardiovascular, neurological and renal). In turn, lactate predicted three (coagulation, cardiovascular and neurological) and PCT two (cardiovascular and renal). CRP did not predict any of the individual components of SOFA. The highest AUROCs were those of MR\u2010proADM and PCT to detect cardiovascular (AUROC, CI95%): MR\u2010proADM (0.82 [0.76\u20100.88]), PCT (0.81 [0.75\u20100.87] (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and renal failure: MR\u2010proADM (0.87 [0.82\u20100.92]), PCT (0.81 [0.75\u20100.86]), (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). None of the biomarkers tested was able to detect hepatic failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with infection, MR\u2010proADM was the biomarker detecting the largest number of SOFA score components, with the exception of hepatic failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13246","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T07:40:31Z","timestamp":1587368431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["MR\u2010 proADM to detect specific types of organ failure in infection"],"prefix":"10.1111","volume":"50","author":[{"given":"Cristina","family":"Andr\u00e9s","sequence":"first","affiliation":[{"name":"Clinical Analysis Service Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Andaluz\u2010Ojeda","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Unit Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Cicuendez","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Unit Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Nogales","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Unit Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Service Hospital Universitario R\u00edo Hortega Valladolid Spain"},{"name":"Group of Biomedical Research in Sepsis (BioSepsis) Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Martin\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Group of Biomedical Research in Sepsis (BioSepsis) Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Spain"},{"name":"Hospital Universitario R\u00edo Hortega de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Almansa","sequence":"additional","affiliation":[{"name":"Group of Biomedical Research in Sepsis (BioSepsis) Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Spain"},{"name":"Hospital Universitario R\u00edo Hortega de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Calvo","sequence":"additional","affiliation":[{"name":"Clinical Analysis Service Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmen","family":"Esteban\u2010Velasco","sequence":"additional","affiliation":[{"name":"Department of General and Gastrointestinal Surgery Hospital Universitario de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Mario","family":"Vaquero\u2010Roncero","sequence":"additional","affiliation":[{"name":"Group of Biomedical Research in Sepsis (BioSepsis) Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Spain"},{"name":"Anesthesiology and Reanimation Service Hospital Universitario de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"R\u00edos\u2010Llorente","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Service Hospital Universitario de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sanchez\u2010Barrado","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Service Hospital Universitario de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mu\u00f1oz\u2010Bellv\u00eds","sequence":"additional","affiliation":[{"name":"Department of General and Gastrointestinal Surgery Hospital Universitario de Salamanca Salamanca Spain"},{"name":"Universidad de Salamanca Edificio de Rectorado Salamanca Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC) Instituto de salud Carlos III (ISCIII) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Aldecoa","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Service Hospital Universitario R\u00edo Hortega Valladolid Spain"},{"name":"Group of Biomedical 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