{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:46:00Z","timestamp":1789609560115,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) caused by SARS\u2010CoV\u20102 was declared in the last weeks as global pandemic. Currently affecting more than 5 000 000 individuals worldwide, COVID\u201019 is most commonly associated with symptoms caused by the acute respiratory distress syndrome (ARDS). As the number of infected individuals increases, we are learning that not only lungs, but also other organs can be affected by the virus. The gastrointestinal symptoms, for example diarrhoea, vomiting, nausea or abdominal pain, are frequent in patients with COVID\u201019. Moreover, alimentary tract symptoms may precede the respiratory presentation of SARS\u2010CoV\u20102 infection. This can lead to delayed diagnosis and inappropriate management of infected patients. In addition, SARS\u2010CoV\u20102 nucleic acid can be detected in faeces of infected patients and rectal swabs are even reported to remain positive for a longer period of time than nasopharyngeal swabs. Here, we aim to provide an update on the gastrointestinal involvement of COVID\u201019 presenting the symptoms that can be encountered in infected patients. We address the role of angiotensin\u2010converting enzyme 2 (ACE2), as a functional receptor for SARS\u2010CoV\u20102, which also was found in the gastrointestinal tract. Finally, we briefly discuss faecal shedding of SARS\u2010CoV\u20102 and its potential role in the pathogenesis of the disease.<\/jats:p>","DOI":"10.1111\/eci.13276","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T11:40:58Z","timestamp":1589456458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["COVID\u201019: Focus on the lungs but do not forget the gastrointestinal tract"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-2800","authenticated-orcid":false,"given":"Wiktor","family":"Smyk","sequence":"first","affiliation":[{"name":"Liver and Internal Medicine Unit Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-0336","authenticated-orcid":false,"given":"Maciej K.","family":"Janik","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-1471","authenticated-orcid":false,"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[{"name":"Clinica Medica \"A. 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