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The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an \"immunological umbrella\" that seems to protect against the infection, through IFN type 1 and NK cell function. To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus. Antimalarials, anti\u2010IL6\u2010Anti\u2010IL6 receptor, anti\u2010IL1, anti\u2010GM\u2010CSF receptor and JAK1\/2\/3 inhibitors, are under investigation in COVID\u2010dedicated clinical trials to control the inflammation raised by SARS\u2010CoV\u20102 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS\u2010CoV\u20102 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI).<\/jats:p>","DOI":"10.1111\/eci.13342","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T21:13:05Z","timestamp":1594329185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Basic immunology may lead to translational therapeutic rationale: SARS\u2010CoV\u20102 and rheumatic diseases"],"prefix":"10.1111","volume":"50","author":[{"given":"Elisa","family":"Gremese","sequence":"first","affiliation":[{"name":"Division of Rheumatology Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"},{"name":"Division of Rheumatology Fondazione Policlinico Universitario A. 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