{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:03Z","timestamp":1753878063929,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>More paediatric\u2010confirmed cases have been reported with the global pandemic of COVID\u201019. This study aims to summarize the key points and supply suggestions on screening paediatric COVID\u201019 patients more appropriately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively included paediatric patients who have accepted SARS\u2010CoV\u20102 RT\u2010PCR testing in Children's Hospital of Chongqing Medical University (30 January 2020 to 13 February 2020) and compared them with paediatric\u2010confirmed COVID\u201019 cases. Besides, a review was carried out by analysing all current literature about laboratory\u2010confirmed paediatric cases with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 46 suspected cases included in the descriptive study. The results of SARS\u2010CoV\u20102 RT\u2010PCR testing were all negative. Compared with paediatric\u2010confirmed cases, the incidence of epidemic history was lower in suspected cases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The rate of fever (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), cough (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), headache or dizziness (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), vomiting (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and abdominal discomfort or distention (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) were more observed in the included suspected children. There were more children having decreased WBC count in the confirmed group. In the literature review, twenty\u2010nine studies were obtained with 488 paediatric COVID\u201019 cases. 88.6% of them had epidemiological history. Cough and fever were the most common symptoms. Compared with older patients, the incidence of fever, respiratory symptoms, lethargy and headache or dizziness was lower, while gastrointestinal symptoms were reported more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with a history of close contact with confirmed cases, manifested as cough and fever should be paid more attention to after excluding infection of other common pathogens. Atypical symptoms should not be over\u2010emphasized in screening paediatric COVID\u201019. More studies are needed for guiding efficient recognition in paediatric COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13351","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T07:10:01Z","timestamp":1595056201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How should our testing behaviour change with time in children in current COVID\u201019 pandemic?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-9542","authenticated-orcid":false,"given":"Yin","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Respiratory Diseases Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of 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and Critical Disorders Chongqing Key Laboratory of Pediatrics National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of Pediatrics National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Critical Care Medicine Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of Pediatrics National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Radiology Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zou","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of Pediatrics National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"Center for Clinical Molecular Medicine Children's Hospital of Chongqing Medical University Chongqing 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