{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:43:58Z","timestamp":1790649838027,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the effects of exercise programmes on pain, function and disease activity in patients with ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We searched PubMed, Embase, CNKI and Wanfang from inception to February 2020. Randomized controlled trials comparing exercises with nonexercise interventions in AS patients were applied. Studies that assessed the visual analogue scale (VAS) pain score, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were included. Outcomes of home\u2010based exercise intervention were also reported independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies met the inclusion criteria in all, including 534 patients (278 exercise, 256 control). Compared with the nonexercise group, exercise group had statistically significant improvements in pain (weighted mean difference [WMD]: \u22121.02 [95% CI: \u22121.50 to \u22120.55]) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 31%, <jats:italic>P<\/jats:italic>\u00a0&lt;.0001), BASDAI\u00a0(WMD: \u22120.85 [95% CI: \u22121.09 to \u22120.61]) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 20%, <jats:italic>P<\/jats:italic>\u00a0&lt;.00001), and BASFI (WMD: \u22120.66 [95% CI: \u22120.95 to \u22120.38]) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0%, <jats:italic>P<\/jats:italic>\u00a0&lt;.00001), but not in CRP and ESR. What's more, home\u2010based exercise programmes had positive impacts on BASFI, BASDAI and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with AS, exercise programmes improve pain, function and disease activity. To confirm the results, more well\u2010designed randomized controlled trials with large number of patients are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13352","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T14:39:01Z","timestamp":1595169541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effects of exercise programmes on pain, disease activity and function in ankylosing spondylitis: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"50","author":[{"given":"Xinmiao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Children's Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nursing Shanghai Jiao Tong University, Shanghai Children's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Children's Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-2318","authenticated-orcid":false,"given":"Yan","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Nursing Affiliated Hospital of Nantong University  Nantong China"},{"name":"Department of Computer Technology Affiliated Hospital of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shanghai Children's Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000475"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201884"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-012-1071-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41042"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0756-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.06.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/86.7.924"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem048"},{"key":"e_1_2_8_14_1","first-page":"449","article-title":"Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? A randomized controlled study","volume":"45","author":"Karapolat H","year":"2009","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbre.2016.09.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100987"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2017.07.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2913-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2344-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1932-9"},{"key":"e_1_2_8_24_1","first-page":"307","article-title":"Observation on the efficacy of drug therapy combined with rehabilitation exercise for ankylosing spondylitis","volume":"14","author":"Li X","year":"2012","journal-title":"Chinese Commun Doctors"},{"key":"e_1_2_8_25_1","first-page":"70","article-title":"Observation of white crane spreads its wings on ankylosing spondylitis","volume":"11","author":"Chen D","year":"2015","journal-title":"Asia\u2010Pacific Tradition Med"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215513512214"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215508101748"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"e_1_2_8_30_1","first-page":"298","article-title":"Exercise and ankylosing spondylitis with New York modified criteria: a systematic review of controlled trials with meta\u2010analysis","volume":"39","author":"Martins NA","year":"2014","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23275"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2470"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151191"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206616"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505066"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-016-1345-z"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2010.487838"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1559966"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-2980-8"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/32590"},{"key":"e_1_2_8_41_1","first-page":"380","article-title":"Effects of an exercise and relaxation aquatic program in patients with spondyloarthritis: a randomized trial","volume":"145","author":"Fern\u00e1ndez GR","year":"2015","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1791-5"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215503cr658oa"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-1078"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.13352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:12:51Z","timestamp":1693851171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/eci.13352"],"URL":"https:\/\/doi.org\/10.1111\/eci.13352","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"2020-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13352"}}