{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:43:05Z","timestamp":1790710985046,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical presentation of COVID\u201019 ranges from a mild, self\u2010limiting disease, to multiple organ failure and death. Most severe COVID\u201019 cases present low lymphocytes counts and high leukocytes counts, and accumulated evidence suggests that in a subgroup of patients presenting severe COVID\u201019, there may be a hyperinflammatory response driving a severe hypercytokinaemia which may be, at least in part, signalling the presence of an underlying endothelial dysfunction. In this context, available data suggest a prognostic role of neutrophil\u2010lymphocyte ratio (NLR) in various inflammatory diseases and oncological processes. Following this rationale, we hypothesized that NLR, as a marker of endothelial dysfunction, may be useful in identifying patients with a poor prognosis in hospitalized COVID\u201019 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective observational study performed at Hospital Universitario HM Puerta del Sur, Madrid, Spain, which included 119 patients with COVID\u201019 from 1 March to 31 March 2020. Patients were categorized according to WHO R&amp;D Expert Group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five (12.1%) patients experienced severe acute respiratory failure requiring respiratory support. Forty\u2010seven (12.6%) patients died. Those with worse outcomes were older (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) and presented significantly higher NLR at admission (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001), greater increase in Peak NLR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and higher increasing speed of NLR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003) compared with follow\u2010up patients. In a multivariable logistic regression, age, cardiovascular disease and C\u2010reactive protein at admission and Peak NLR were significantly associated with death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NLR is an easily measurable, available, cost\u2010effective and reliable parameter, which continuous monitoring could be useful for the diagnosis and treatment of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13404","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T12:22:47Z","timestamp":1601036567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Prognostic implications of neutrophil\u2010lymphocyte ratio in COVID\u201019"],"prefix":"10.1111","volume":"51","author":[{"given":"Sara","family":"Jimeno","sequence":"first","affiliation":[{"name":"Pediatrics Department Hospital Universitario HM Puerta del Sur M\u00f3stoles, Madrid Spain"},{"name":"Facultad de Medicina Universidad CEU San Pablo Madrid Spain"},{"name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales Madrid Spain"},{"name":"Pediatrics Department Hospital Universitario HM Nens Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Castellano","sequence":"additional","affiliation":[{"name":"Cardiology Department Facultad de Medicina Centro Nacional de Investigaciones Cardiovasculares Hospital Universitario HM Montepr\u00edncipe Grupo HM Hospitales Fundaci\u00f3n de Investigaci\u00f3n 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