{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:30Z","timestamp":1787014110535,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470905"],"award-info":[{"award-number":["81470905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic sphincterotomy (EST) can destroy sphincter of Oddi (SO) structure and function. The purpose of this study was to assess the feasibility of endoscopic endoclip papilloplasty (EEPP) in restoring SO function after EST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seven 26\u2010week\u2010old domestic pigs were divided into control and EEPP groups. Necropsy and haematoxylin\u2010eosin staining plus anti\u2010\u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) staining of papilla and sphincter of Oddi manometry (SOM) were conducted in animals at three independent time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EST and EEPP were safely performed in all 7 pigs without serious adverse events. For primary outcome, compared to the controls, EEPP generated smaller dilation and less inflammation. Fibrous repair of the papilla was observed at 24\u00a0weeks after EEPP. For secondary outcome, in the control group, SO basal pressure (17.25\u00a0\u00b1\u00a018.14 to 5.50\u00a0\u00b1\u00a00.71\u00a0mmHg), SO contraction amplitude (46.00\u00a0\u00b1\u00a019.20 to 34.50\u00a0\u00b1\u00a048.79\u00a0mmHg), peak (4.50\u00a0\u00b1\u00a04.04 to 1.50\u00a0\u00b1\u00a02.12) and frequency (3.05\u00a0\u00b1\u00a03.29 to 1.41\u00a0\u00b1\u00a02.19\/min) were reduced after EST. Further reductions to almost 0 of these SOM parameters were observed 3\u00a0weeks later, including common bile duct pressure and SO contraction period. In contrast, in the EEPP group, these manometric data were recovered to pre\u2010EST levels, including CBD pressure (11.5\u00a0\u00b1\u00a07.31 vs 11\u00a0\u00b1\u00a02.16\u00a0mmHg), SO pressure (17.50\u00a0\u00b1\u00a017.75 vs 18.20\u00a0\u00b1\u00a021.39\u00a0mmHg) and SO contraction amplitude (53.67\u00a0\u00b1\u00a021.54 vs 60.00\u00a0\u00b1\u00a036.08\u00a0mmHg). However, no significant differences were observed between control and EEPP groups by Student t test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this porcine study, EEPP accelerated and improved papillary healing after EST, further preserved SO function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13408","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T05:37:10Z","timestamp":1600753030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Endoscopic endoclip papilloplasty preserves sphincter of oddi function"],"prefix":"10.1111","volume":"51","author":[{"given":"Yingchun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital Beijing 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