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We aimed to evaluate the association between\n                      <jats:italic>OLFM4<\/jats:italic>\n                      single nucleotide polymorphisms (SNPs) and septic shock\u2010related death in 175 patients who underwent major surgery, as well as its performance in predicting mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We carried out a retrospective study. A total of seven\n                      <jats:italic>OLFM4<\/jats:italic>\n                      SNPs were genotyped by Agena Bioscience's MassARRAY platform. Statistical analysis was performed by Kaplan\u2010Meier and Cox regression tests. The diagnostic performance for predicting septic shock\u2010related death was evaluated by the area under the receiver\u2010operating characteristic (AUROC) curve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with rs17552047 A allele and rs1891944 TT genotype had higher survival than patients with rs17552047 G allele (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.024) and patients with rs1891944 CC\/CT genotype (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.038). However, only rs17552047 was associated with a lower risk of death under an additive inheritance model (adjusted hazard ratio [aHR]\u00a0=\u00a00.44, 95% CI\u00a0=\u00a00.27\u20100.71). The multivariate model with the most significant clinical variables (lactate, chronic kidney disease, peritonitis, heart disease and elective surgery) showed an AUROC of 0.776 for predicting septic shock\u2010related death. When we added the\n                      <jats:italic>OLFM4<\/jats:italic>\n                      rs17552047 SNP to the previous model, the AUROC was 0.811 and was close to reaching significant differences with the previous model (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.065).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>OLFM4<\/jats:italic>\n                      rs17552047 A allele predicts septic shock survival in patients who underwent major surgery. Furthermore, rs17552047, together with clinical variables, could be useful to predict the outcome of septic shock.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13416","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T04:34:55Z","timestamp":1601440495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>OLFM4<\/i>\n                    polymorphisms predict septic shock survival after major surgery"],"prefix":"10.1111","volume":"51","author":[{"given":"Felipe","family":"P\u00e9rez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad Centro Nacional de Microbiolog\u00eda Instituto de Salud Carlos III Majadahonda 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