{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:50:15Z","timestamp":1791946215777,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016698","name":"Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province","doi-asserted-by":"publisher","award":["U1903118"],"award-info":[{"award-number":["U1903118"]}],"id":[{"id":"10.13039\/100016698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC2000300"],"award-info":[{"award-number":["2018YFC2000300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10302 302001004"],"award-info":[{"award-number":["2018ZX10302 302001004"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the incidence of co\u2010existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co\u2010existent PTB and lung cancer (PTB\u2010lung cancer) cases in a case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 125 PTB\u2010lung cancer patients were enrolled by Beijing Chest Hospital as the case group between January 2012 and December 2016. Age\u2010 and sex\u2010matched PTB\u2010only (N\u00a0=\u00a0125) and lung cancer\u2010only (N\u00a0=\u00a0125) patients were selected as the control groups. Data were collected from the medical records and computed tomography (CT) reports. The case group was further categorized into three sub\u2010groups according to the diagnosis intervals between previous PTB and lung cancer (&lt;1\u00a0year, 1\u201010\u00a0years, and\u00a0&gt;\u00a010\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Compared with both controls of PTB\u2010only and lung cancer\u2010only patients, the PTB\u2010lung cancer case group had significantly higher proportions of patients with irritant cough, expectoration, hemoptysis, fever and CT features of irregular mass and pleural thickening. For PTB patients, fibrous calcification (OR, 2.193; 95%CI, 1.168\u20104.117) was associated with higher odds of lung cancer (<jats:italic>P<\/jats:italic>\u2010value\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distinct clinical symptoms and CT tests may help with the early diagnosis of PTB\u2010lung cancer cases. PTB patients with fibrous calcification may have a higher risk of lung cancer. Further multicenter prospective studies are required to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13432","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:38:05Z","timestamp":1602704285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associated factors of co\u2010existent pulmonary tuberculosis and lung cancer: A case\u2010control study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-7494","authenticated-orcid":false,"given":"Lijun","family":"Zheng","sequence":"first","affiliation":[{"name":"National Tuberculosis Clinical Lab of China Beijing Chest Hospital Capital Medical University  Beijing China"},{"name":"National Tuberculosis Clinical Lab of China Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-0936","authenticated-orcid":false,"given":"Jinfeng","family":"Yin","sequence":"additional","affiliation":[{"name":"National Tuberculosis Clinical Lab of China Beijing Chest Hospital Capital Medical University  Beijing China"},{"name":"National Tuberculosis Clinical Lab of China Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-8685","authenticated-orcid":false,"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Statistics Ren'min University of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-8368","authenticated-orcid":false,"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Tuberculosis Clinical Lab of China Beijing Chest Hospital Capital Medical University  Beijing China"},{"name":"National Tuberculosis Clinical Lab of China Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-4146","authenticated-orcid":false,"given":"Puqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing You'an Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-5011","authenticated-orcid":false,"given":"Ziqing","family":"Kang","sequence":"additional","affiliation":[{"name":"Beijing You'an Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-5493","authenticated-orcid":false,"given":"Pingxin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Chest Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-9009","authenticated-orcid":false,"given":"Weimin","family":"Li","sequence":"additional","affiliation":[{"name":"National Tuberculosis Clinical Lab of China Beijing Chest Hospital Capital Medical University  Beijing China"},{"name":"National Tuberculosis Clinical Lab of China Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology School of Public Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-7078","authenticated-orcid":false,"given":"Chao","family":"Cai","sequence":"additional","affiliation":[{"name":"Beijing You'an Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Global tuberculosis report 2019 (World Health Organization 2019).https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/329368\/9789241565714-eng.pdf?ua=1. 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