{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:50:10Z","timestamp":1776286210887,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no data on the clinical profile, prognosis and risk factors of such patients during hospitalization for COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Subanalysis of the international \u2018real\u2010world\u2019 HOPE COVID\u201019 registry. All patients with prior OAC at hospital admission for COVID\u201019 were suitable for the study. All\u2010cause mortality was the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1002 patients included, 110 (60.9% male, median age of 81.5 [IQR 75\u201087] years, median Short\u2010Form Charlson Comorbidity Index [CCI] of 1 [IQR 1\u20103]) were on OAC at admission, mainly for atrial fibrillation and venous thromboembolism. After propensity score matching, 67.9% of these patients died during hospitalization, which translated into a significantly higher mortality risk compared to patients without prior OAC (HR 1.53, 95% CI 1.08\u20102.16). After multivariate Cox regression analysis, respiratory insufficiency during hospitalization (HR 6.02, 95% CI 2.18\u201016.62), systemic inflammatory response syndrome (SIRS) during hospitalization (HR 2.29, 95% CI 1.34\u20103.91) and the Short\u2010Form CCI (HR 1.24, 95% CI 1.03\u20101.49) were the main risk factors for mortality in patients on prior OAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to patients without prior OAC, COVID\u201019 patients on OAC therapy at hospital admission showed lower survival and higher mortality risk. In these patients on OAC therapy, the prevalence of several comorbidities is high. Respiratory insufficiency and SIRS during hospitalization, as well as higher comorbidity, pointed out those anticoagulated patients with increased mortality risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13436","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T17:10:07Z","timestamp":1603213807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID\u201019"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-6241","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rivera\u2010Caravaca","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV  Murcia 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