{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:20Z","timestamp":1753878680095,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatoid arthritis (RA) is associated with increased risk of infections. Screening for oral (dental and\/or sinus) infection could be proposed before biologic disease\u2010modifying antirheumatic drugs (bDMARDs) initiation but is not systematically recommended. The aim of our study was to assess the prevalence of oral infection in RA patients requiring bDMARDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was a monocentric retrospective study. We included patients with RA and active disease requiring bDMARDs. Dental infection and sinusitis were assessed by a stomatologist and otorhinolaryngologist after clinical, panoramic dental X\u2010ray and sinus CT evaluation. Factors associated with oral infections were analysed in uni\u2010 and multivariate models, estimating odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 223 RA patients (79.4% women, mean disease duration 8.9\u00a0\u00b1\u00a08.6\u00a0years). The mean age was 54.4\u00a0\u00b1\u00a010.9\u00a0years and mean Disease Activity Score in 28 joints 5.5\u00a0\u00b1\u00a02.6. Systematic dental screening revealed infection requiring treatment before bDMARDs initiation in 46 (20.9%) patients. Sinusitis was diagnosed by the otorhinolaryngologist in 33 (14.8%) patients. Among the 223 patients, 69 (30.9%) had dental and\/or sinus infection. On univariate analysis, active smoking was associated with increased probability of oral infection (OR\u00a0=\u00a02.16 [95% CI 1.02\u20104.57], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.038) and methotrexate with reduced probability (OR\u00a0=\u00a00.43 [95% CI 0.23\u20100.81], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). On multivariate analysis, no RA variables were associated with oral infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, asymptomatic oral infection was confirmed in one third of RA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13437","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T02:45:02Z","timestamp":1603334702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screening of dental and sinus infections in rheumatoid arthritis"],"prefix":"10.1111","volume":"51","author":[{"given":"Elise","family":"Descamps","sequence":"first","affiliation":[{"name":"Rheumatology Department DMU Locomotion Bichat Hospital (APHP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Gorlier","sequence":"additional","affiliation":[{"name":"Rheumatology Department DMU Locomotion Bichat Hospital (APHP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-1503","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Rheumatology Department DMU Locomotion Bichat Hospital (APHP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Rheumatology Department DMU Locomotion Bichat Hospital (APHP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dieud\u00e9","sequence":"additional","affiliation":[{"name":"Rheumatology Department DMU Locomotion Bichat Hospital (APHP) Paris 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