{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:56:06Z","timestamp":1782770166818,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dermatomyositis (DM) and polymyositis (PM) are two rare autoimmune disorders occasionally described with dysthyroidism; however, no solid evidence still proves such an association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the prevalence of dysthyroidism among DM\/PM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>A nation\u2010wide case\u2010control study was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the Clalit Health Services health records database, we extracted 2085 (DM\u00a0=\u00a01475 (70.7%), PM\u00a0=\u00a0610 (29.3%)) PM\/DM cases and 10\u00a0193 sex\u2010age matched controls in the period 2000\u20102018. Both univariate and multivariate analyses were performed to evaluate the link dysthyroidism and PM\/DM. Survival analysis was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rate of hyperthyroidism was significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0097) higher in cases (n\u00a0=\u00a040, 1.9%) with respect to controls (n\u00a0=\u00a0123, 1.2%). Similarly, the rate of hypothyroidism was significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) associated with cases (n\u00a0=\u00a0234, 11.2%) when compared to controls (n\u00a0=\u00a0853, 8.4%). At the multivariate logistic regression analysis, both DM (OR 1.31 [95%CI 1.07\u20101.60],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0087) and PM (OR 1.54 [95%CI 1.21\u20101.95],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004) were significantly associated with hypothyroidism, whereas DM (OR 1.70 [95%CI 1.10\u20102.61],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0165) but not PM (OR 1.45 [0.83\u20102.55],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.1947) was found to be associated with hyperthyroidism. Subjects with PM and positive for anti\u2010Sj\u00f6gren's syndrome\u2010related antigen A (SSA) auto\u2010antibody displayed a significant risk of developing hyperthyroidism (OR 5.85 [95%CI 1.02\u201033.74],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0480), whereas individuals with DM and positive for antinuclear antibody (ANA) had a higher risk of developing hyperthyroidism (OR 2.65 [95%CI 1.00\u20107.03],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0498).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Physicians treating PM\/DM patients should consider screening for thyroid dysfunction on a regular basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13460","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T04:54:59Z","timestamp":1607316899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysthyroidism in dermato\/polymyositis patients: A case\u2010control study"],"prefix":"10.1111","volume":"51","author":[{"given":"Abdulla","family":"Watad","sequence":"first","affiliation":[{"name":"Department of Medicine \u2018B\u2019 The Zabludowicz Center for Autoimmune Diseases Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Section of Musculoskeletal Disease Leeds Institute of Molecular Medicine University of Leeds NIHR Leeds Musculoskeletal Biomedical Research Unit Chapel Allerton Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Bragazzi","sequence":"additional","affiliation":[{"name":"Laboratory for Industrial and Applied Mathematics (LIAM) Department of Mathematics and Statistics York University Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Damiani","sequence":"additional","affiliation":[{"name":"Clinical Dermatology IRCCS Galeazzi Orthopedic Institute Milan Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-6137","authenticated-orcid":false,"given":"Ella","family":"Nissan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Comaneshter","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel Aviv Faculty of Health 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