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However, other programming windows have been recognized in the last years, namely lactation, infancy, adolescence and even preconception. Although the concept has been developed in order to study the impact of foetal calorie restriction in adult life, it is now recognized that maternal overweight during programming windows is also harmful to the offspring. This article explores and summarizes the current knowledge about the impact of maternal obesity and obesogenic diets during lactation in the metabolic programming towards the development of metabolic syndrome in the adult life. The impact of maternal obesity and obesogenic diets in milk quality is discussed, including the alterations in specific micro and macronutrients, as well as the impact of such alterations in the development of metabolic syndrome\u2010associated features in the newborn, such as insulin resistance and adiposity. Moreover, the impact of milk quality and formula feeding in infants\u2019 gut microbiota, immune system maturation and in the nutrient\u2010sensing mechanisms, namely those related to gut hormones and leptin, are also discussed under the current knowledge.<\/jats:p>","DOI":"10.1111\/eci.13482","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T19:48:59Z","timestamp":1608666539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Lactation as a programming window for metabolic syndrome"],"prefix":"10.1111","volume":"51","author":[{"given":"Catalina","family":"Pic\u00f3","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity) University of the Balearic Islands Palma (Mallorca) Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Illes Balears (IdISBa) Palma (Mallorca) Spain"},{"name":"CIBER 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