{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:52:02Z","timestamp":1784242322386,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with functional dyspepsia (FD) are more likely to have persistent depression, yet whether depression and antidepressant treatments are associated with subsequent risk of FD remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using population\u2010based insurance administrative data of Taiwan, an 11\u2010year historic cohort study was assembled, comparing cases aged 18 and above with the diagnosis of depressive disorder, to a propensity score\u2010matched sample of adults without depression. Incident FD as a primary diagnosis was ascertained. Hazard ratios of FD were calculated using Cox regression models by age, gender, other comorbidities, nonsteroidal anti\u2010inflammatory medications, antidepressants and antidiabetic agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20,197 people with depressive disorder and 20,197 propensity score\u2010matched comparisons without depression were followed up. The incidence of FD was 1.7\u2010fold greater in the depressive cohort than in comparisons (12.9 versus 7.57 per 1000 person\u2010years), with an adjusted hazard ratio (aHR) of 2.16 (95% confidence interval (CI) 1.93~2.41). Increased risks were significant regardless of comorbidities or medication uses, the highest in the untreated depression group compared to the group without depression, with an aHR of 2.51(95% CI 2.15~2.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This population\u2010based study showed that patients with depressive disorder are at elevated risk of FD. Antidepressant treatment could reduce the risk of FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13506","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T16:56:23Z","timestamp":1612544183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Functional dyspepsia in depression: A population\u2010based cohort study"],"prefix":"10.1111","volume":"51","author":[{"given":"Kai\u2010Liang","family":"Kao","sequence":"first","affiliation":[{"name":"Department of Pediatrics Far Eastern Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung\u2010Chang","family":"Sung","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Health Services Administration College of Public Health China Medical University  Taichung Taiwan"},{"name":"Department of 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