{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:22Z","timestamp":1753878082432,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005934","name":"Malm\u00f6 H\u00f6gskola","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005934","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The identification of novel predictors of poor outcome may help stratify cardiovascular risk. Aim was to evaluate the individual contribution of blood cell count parameters, as well as their clustering, on the risk of death and cardiovascular events over the long term in the population\u2010based Malm\u00f6 Diet and Cancer Study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 30,447 individuals (age 57\u00a0\u00b1\u00a08\u00a0years), we assessed the incidence of all\u2010cause death (primary endpoint) and major adverse cardiovascular events (MACE, secondary outcome measure) according to absence or presence of one, two and three factors at baseline out of the following: anaemia, leukocytosis and thrombocytosis. Median follow\u2010up was 16\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentages of all\u2010cause death were 19.5% in individuals without factors, 21.3% in those with one factor, 27.4% with two and 46.4% with three (log\u2010rank test <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The crude incidence of MACE was 28.0%, 29.2%, 35.5% and 57.1%, respectively (log\u2010rank test <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). At multivariate analysis, we found a stepwise increase in overall mortality with increasing number of prevalent factors (one factor: HR 1.23, 95% CI 1.14\u20101.31, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; two factors: 1.61, 1.37\u20101.89, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; three factors: 2.69, 1.44\u20105.01, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, vs no factor). Similar findings were observed for the incidence of MACE (one factor: adjusted HR 1.18, 95% CI 1.11\u20101.24, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; two factors: 1.52, 1.33\u20101.76, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; three factors: 2.03, 1.21\u20103.67, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, vs no factor).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The easily assessable clustering of anaemia, leukocytosis and thrombocytosis heralds higher incidence of death and adverse cardiovascular events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13562","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T19:40:11Z","timestamp":1620502811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clustering of blood cell count abnormalities and future risk of death"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-3968","authenticated-orcid":false,"given":"Giuseppe","family":"Patti","sequence":"first","affiliation":[{"name":"Chair of Cardiology University of Eastern Piedmont and Maggiore della Carit\u00e0 Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Lio","sequence":"additional","affiliation":[{"name":"Chair of Cardiology University of Eastern Piedmont and Maggiore della Carit\u00e0 Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences \u201cG. d'Annunzio\u201d University Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences G. d'Annunzio University Chieti Italy"},{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Renda","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences G. d'Annunzio University Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Hamrefors","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-574X","authenticated-orcid":false,"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"University Cardiology Division University of Pisa Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"},{"name":"Department of Cardiology Sk\u00e5ne University Hospital Malm\u00f6 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