{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:39:27Z","timestamp":1773275967467,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to assess the effects of a lacto\u2010ovo\u2010vegetarian diet (VD), compared to a Mediterranean diet (MD), on kidney function in a group of subjects with medium\u2010to\u2010low cardiovascular risk profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 107 subjects (82 women, 25 men; median age 52) who followed a VD (n\u00a0=\u00a054) and a MD (n\u00a0=\u00a053) for 3\u00a0months in the CARDIVEG study, a randomized, open, crossover trial that compared the effects of these 2 diets on cardiovascular disease risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect of the two diets on kidney function markers was evaluated by conducting a general linear model for repeated measurements adjusted for possible confounding factors such as age, sex, physical activity, alcohol, smoking, hypertension, LDL cholesterol, glucose and body weight change. A significant reduction in creatinine (\u22125.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), urea nitrogen levels (\u22129%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), blood urea nitrogen (BUN) (\u22128.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and BUN\/creatinine ratio (\u22125.8%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and an increase in estimated glomerular filtration rate (eGFR) (+3.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) was observed during the VD period. On the contrary, no significant changes were noted in the MD group. Variations obtained in the two dietary interventions were significantly different (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) for creatinine levels, BUN\/creatinine and eGFR, for which opposite trends were observed in the VD and MD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a selected group of subjects with medium\u2010to\u2010low cardiovascular risk profile, a 3\u00a0month VD period determined significant improvements in kidney function markers. Further trials are needed to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13576","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T03:32:40Z","timestamp":1620358360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of vegetarian versus Mediterranean diet on kidney function: Findings from the CARDIVEG study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-2527","authenticated-orcid":false,"given":"Monica","family":"Dinu","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Colombini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuditta","family":"Pagliai","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Giangrandi","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cesari","sequence":"additional","affiliation":[{"name":"Atherohtombotic Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"Atherohtombotic Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betti","family":"Giusti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"Atherohtombotic Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"Atherohtombotic Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sofi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"Clinical Nutrition Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.05.047"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0297-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000574"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00530119"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081877"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0fo00032a"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.02.334"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030088"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1353-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_8_15_1","unstructured":"AcquistucciR.Societ\u00e0 Italiana di nutrizione umana SICS.LARN livelli di assunzione di riferimento di nutrienti e energia per la popolazione Italiana. 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