{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:19:41Z","timestamp":1789150781011,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the long\u2010term outcomes of mitral valve replacement (MVR) in native mitral valve infective endocarditis (IE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre, population\u2010based cohort register study consisted of 1233 consecutive adult patients treated with first\u2010time MVR in Finland. Mitral valve IE was diagnosed in 170 of these patients. Propensity score matching resulted in 134 pairs with balanced baseline characteristics. The median follow\u2010up was 6.1\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010operative native mitral valve IE was associated with an increased hazard of 10\u2010year mortality (38.8% vs 30.5%; HR 2.13; CI 1.17\u20103.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013) after MVR. Occurrence of major bleeding was higher in IE patients (26.0%) vs non\u2010IE patients (23.4%) during the 10\u2010year follow\u2010up (HR 2.80; CI 1.01\u20107.77; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048). Hospital admission duration after MVR was longer in IE patients (median 28 vs 11\u00a0days; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Cumulative ischaemic stroke rate was similar between patient groups (12.1% in IE vs 15.1% in non\u2010IE; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.493). Re\u2010sternotomy was performed in 13.4% of IE patients and 9.0% of non\u2010IE patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.261).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with native mitral valve IE have a higher risk of death and major bleeding after MVR than matched patients without IE. Results highlight the importance of complication prevention in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13577","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T08:21:37Z","timestamp":1619857297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Infective endocarditis and outcomes of mitral valve replacement"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-1141","authenticated-orcid":false,"given":"Vesa","family":"Anttila","sequence":"first","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-6089","authenticated-orcid":false,"given":"Markus","family":"Malmberg","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmo","family":"Gunn","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Rautava","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Turku Turku Finland"},{"name":"Turku Clinical Research Centre Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Kyt\u00f6","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku Turku Finland"},{"name":"Research Center of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland"},{"name":"Center for Population Health Research Turku University Hospital and University of Turku Turku Finland"},{"name":"Administrative Center Hospital District of Southwest Finland Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"issue":"65","key":"e_1_2_9_2_1","first-page":"2070","article-title":"Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011","volume":"2015","author":"Pant S","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026811"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.12.046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv319"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2000400"},{"key":"e_1_2_9_8_1","first-page":"1241","article-title":"2016 the American Association for Thoracic Surgery (AATS) consensus guidelines: Surgical treatment of infective endocarditis: Executive summary","volume":"1543","author":"AATS Surgical treatment of infective endocarditis consensus guidelines writing committee chairs","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-019-1029-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.08.060"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.04.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx341"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu281"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy242"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.04.064"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13728"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy156"},{"key":"e_1_2_9_19_1","first-page":"e13476","article-title":"Surgical aortic valve replacement and infective endocarditis","author":"Malmberg M","year":"2020","journal-title":"Eur J Clin Invest"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz122"},{"key":"e_1_2_9_21_1","first-page":"1186","article-title":"Increased risk of ischemic stroke after treatment of infective endocarditis: A Danish, nationwide, propensity score\u2010matched cohort study","volume":"70","author":"Klein CF","year":"2020","journal-title":"Clin Infect Dis"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494812456637"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:10:41Z","timestamp":1692828641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/eci.13577"],"URL":"https:\/\/doi.org\/10.1111\/eci.13577","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"2021-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13577"}}