{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:31:35Z","timestamp":1769095895803,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared the outcomes and adverse events of TAVI patients based on the discharge and long\u2010term antiplatelet or anticoagulant treatment regimens (single antiplatelet [SAPT] vs. dual antiplatelet [DAPT] vs. anticoagulation [OAC] vs. no treatment [NT]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The outcome of 532 consecutive patients treated with TAVI was evaluated. As the main study endpoint, the 1\u2010year all\u2010cause mortality was chosen to compare the different discharge treatment regimens and the 3\u2010year all\u2010cause mortality to compare the different long\u2010term treatment regimens. The secondary endpoints were adverse events as defined by the Valve Academic Research Consortium\u2010II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010year survival after TAVI was highest amongst patients treated with DAPT compared to SAPT (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and OAC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), and patients under OAC demonstrated improved 1\u2010year survival over patients treated with SAPT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Furthermore, there was a strong trend towards improved 3\u2010year survival for patients in the OAC cohort treated with non\u2013vitamin K antagonists compared to vitamin K antagonists (N\u2010VKAs vs. VKA; log\u2010rank <jats:italic>P<\/jats:italic>\u00a0=\u00a0.056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lower all\u2010cause mortality for DAPT within the first year and N\u2010VKAs over VKA within the first 3\u00a0years warrant considerable attention in further recommendations of antithrombotic and anticoagulation regimens after TAVI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13589","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T08:25:56Z","timestamp":1623572756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of antiplatelet and antithrombotic regimen after TAVI"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-4914","authenticated-orcid":false,"given":"Markus","family":"Mach","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"},{"name":"Heart Team Vienna, Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-7130","authenticated-orcid":false,"given":"Victoria","family":"Watzal","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Cuhaj","sequence":"additional","affiliation":[{"name":"Heart Team Vienna, Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-0197","authenticated-orcid":false,"given":"Waseem","family":"Hasan","sequence":"additional","affiliation":[{"name":"Heart Team Vienna, Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna Austria"},{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Poschner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Szalkiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-8575","authenticated-orcid":false,"given":"Andreas","family":"Strouhal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinic Floridsdorf, Karl Landsteiner Institute for Cardiovascular &amp; Intensive Care Research Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Adlbrecht","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinic Floridsdorf, Karl Landsteiner Institute for Cardiovascular &amp; Intensive Care Research Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Delle\u2010Karth","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinic Floridsdorf, Karl Landsteiner Institute for Cardiovascular &amp; Intensive Care Research Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Grabenw\u00f6ger","sequence":"additional","affiliation":[{"name":"Heart Team Vienna, Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna Austria"},{"name":"Medical Faculty Sigmund Freud University Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-027X","authenticated-orcid":false,"given":"Bernhard","family":"Winkler","sequence":"additional","affiliation":[{"name":"Heart Team Vienna, Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.02.024"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"576","article-title":"An audit of anticoagulation practice among UK cardiothoracic consultant surgeons following valve replacement\/repair","volume":"14","author":"Vaughan P","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.01.049"},{"issue":"5","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1160\/TH10-04-0217","article-title":"Peri\u2010operative management of antiplatelet therapy in patients with coronary artery disease: joint position paper by members of the working group on Perioperative Haemostasis of the Society on Thrombosis and Haemostasis Research (GTH), the working group on Perioperative Coagulation of the Austrian Society for Anesthesiology, Resuscitation and Intensive Care (\u00d6GARI) and the Working Group Thrombosis of the European Society for Cardiology (ESC)","volume":"105","author":"Korte W","year":"2011","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-015-0050-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.04.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2017-000748"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00799-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90355-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I2A40"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_2_7_16_1","unstructured":"HayesAF.PROCESS: A versatile computational tool for observed variable mediation moderation and conditional process modeling [White paper].2012. 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