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This test has been validated mostly in hospital settings. Here we have evaluated Fever\u20107 to identify the presence of respiratory viral infections in a Community Health Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in the \u201cServicio de Urgencias de Atenci\u00f3n Primaria\u201d in Salamanca, Spain. Patients with clinical signs of respiratory infection and at least one point in the National Early Warning Score were recruited. Fever\u20107 mRNAs were profiled on a Nanostring nCounter\u00ae SPRINT instrument from blood collected upon patient enrolment. Viral diagnosis was performed on nasopharyngeal aspirates (NPAs) using the Biofire\u2010RP2 panel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A respiratory virus was detected in the NPAs of 66 of the 100 patients enrolled. Median National Early Warning Score was 7 in the group with no virus detected and 6.5 in the group with a respiratory viral infection (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). The Fever\u20107 score yielded an overall AUC of 0.81 to predict a positive viral syndromic test. The optimal operating point for the Fever\u20107 score yielded a sensitivity of 82% with a specificity of 71%. Multivariate analysis showed that Fever\u20107 was a robust marker of viral infection independently of age, sex, major comorbidities and disease severity at presentation (OR [CI95%], 3.73 [2.14\u20106.51], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fever\u20107 is a promising host immune mRNA signature for the early identification of a respiratory viral infection in the community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13626","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T08:59:32Z","timestamp":1623574772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A host transcriptomic signature for identification of respiratory viral infections in the community"],"prefix":"10.1111","volume":"51","author":[{"given":"Raquel","family":"Almansa","sequence":"first","affiliation":[{"name":"Group for Biomedical Research in Sepsis (BioSepsis) Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Gerencia Regional de Salud  Salamanca Spain"},{"name":"Hospital Universitario R\u00edo Hortega Gerencia Regional de Salud  Valladolid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Herrero\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Urgencias de Atenci\u00f3n Primaria de Salamanca (SUAP). Gerencia de Atenci\u00f3n Primaria de Salamanca Gerencia Regional de salud de Castilla y Le\u00f3n (SACyL)  Salamanca Spain"},{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Gerencia de Atenci\u00f3n Primaria de Salamanca Gerencia Regional de salud de Castilla y Le\u00f3n (SACyL)  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misericordia","family":"Mart\u00ednez\u2010Hu\u00e9lamo","sequence":"additional","affiliation":[{"name":"Servicio de Urgencias de Atenci\u00f3n Primaria de Salamanca (SUAP). Gerencia de Atenci\u00f3n Primaria de Salamanca Gerencia Regional de salud de Castilla y Le\u00f3n (SACyL)  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Pilar","family":"Vicente\u2010Andres","sequence":"additional","affiliation":[{"name":"Servicio de Urgencias de Atenci\u00f3n Primaria de Salamanca (SUAP). 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