{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:25:14Z","timestamp":1790115914262,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transthyretin\u2010related cardiac amyloidosis (TTR\u2010CA) is thought to be particularly common in specific at\u2010risk conditions, including aortic stenosis (AS), heart failure with preserved ejection fraction (HFpEF), carpal tunnel syndrome (CTS) and left ventricular hypertrophy or hypertrophic cardiomyopathy (LVH\/HCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic revision of the literature, including only prospective studies performing TTR\u2010CA screening with bone scintigraphy in the above\u2010mentioned conditions. Assessment of other forms of CA was also evaluated. For selected items, pooled estimates of proportions or means were obtained using a meta\u2010analytic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies (3 AS, 2 HFpEF, 2 CTS and 2 LVH\/HCM) accounting for 1375 screened patients were included. One hundred fifty\u2010six (11.3%) TTR\u2010CA patients were identified (11.4% in AS, 14.8% in HFpEF, 2.6% in CTS and 12.9% in LVH\/HCM). Exclusion of other forms of CA and use of genetic testing was overall puzzled. Age at TTR\u2010CA recognition was significantly older than that of the overall screened population in AS (86 vs. 83\u00a0years, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04), LVH\/HCM (75 vs. 63, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and CTS (82 vs. 71), but not in HFpEF (83 vs. 79, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.35). In terms of comorbidities, hypertension, diabetes and atrial fibrillation were highly prevalent in TTR\u2010CA\u2010diagnosed patients, as well as in those with an implanted pacemaker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Screening with bone scintigraphy found an 11\u201315% TTR\u2010CA prevalence in patients with AS, HFpEF and LVH\/HCM. AS and HFpEF patients were typically older than 80\u00a0years at TTR\u2010CA diagnosis and frequently accompanied by comorbidities. Several studies showed limitations in the application of recommended TTR\u2010CA diagnostic algorithm, which should be addressed in future prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13665","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T13:17:20Z","timestamp":1628947040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Yield of bone scintigraphy screening for transthyretin\u2010related cardiac amyloidosis in different conditions: Methodological issues and clinical implications"],"prefix":"10.1111","volume":"51","author":[{"given":"Giacomo","family":"Tini","sequence":"first","affiliation":[{"name":"Cardiology Unit Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"Division of Cardiology Sapienza University of Rome Sant\u2019Andrea Hospital  Rome 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