{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:53:20Z","timestamp":1767851600392,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007496","name":"Fondazione Cassa di Risparmio di Genova e Imperia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["2754291"],"award-info":[{"award-number":["2754291"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High circulating levels of cellular adhesion molecules (CAMs) in non\u2010small cell lung cancer (NSCLC) have been supposed to act as a negative prognostic factor. Here, we explored the predictive role of pre\u2010treatment levels of CAMs in previously treated patients receiving nivolumab for NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Seventy one patients with advanced NSCLC, treated with nivolumab at the dose of 3\u00a0mg\/kg every 14\u00a0days, were enrolled. Maximum follow\u2010up time was 3\u00a0years. Serum levels of Vascular Cell Adhesion Molecule\u20101 (VCAM\u20101) and Intracellular Adhesion Molecule\u20101 (ICAM\u20101) were measured at baseline and before each nivolumab administration. Endpoints of the study were a composite outcome of survival \u22652\u00a0years or absence of disease progression at the end of the follow\u2010up, and the overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Composite outcome and overall survival were positively associated with VCAM\u20101 baseline levels and with the reduction of VCAM\u20101 during the treatment. After adjustment for potential confounders, the change in VCAM\u20101\u00a0serum levels during the treatment was an independent predictor of overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High baseline serum levels of VCAM\u20101 are associated with a longer survival in patients treated with nivolumab as second line treatment for NSCLC. Surviving patients experience also a significant reduction in CAMs expression during the treatment. Hence, CAMs might be promising prognostic factors in patients with NSCLC underoing immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13668","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T13:07:55Z","timestamp":1628946475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum levels of VCAM\u20101 are associated with survival in patients treated with nivolumab for NSCLC"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4078","authenticated-orcid":false,"given":"Federico","family":"Carbone","sequence":"first","affiliation":[{"name":"First Clinic of internal Medicine Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genoa \u2013 Italian Cardiovascular Network  Genoa 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