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The combined odds ratios or mean differences of all IVUS characteristics were calculated with random\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight studies involving 5434 subjects, and 5618 lesions were included. Culprit lesions in acute coronary syndromes have larger plaque areas and remodeling indexes (MD\u00a0=\u00a00.13 [0.08; 0.17], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and contained larger necrotic cores (MD\u00a0=\u00a00.67 (95% CI 0.19;1.15), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) that stable angina culprit lesions. In acute patients, culprit plaques were also more remodeled, had larger necrotic cores and had more frequently a Thin\u2010Cap Fibroatheroma morphology (OR\u00a0=\u00a01.79 (95% CI 1.21; 2.65), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) than non\u2010culprit lesions. Non\u2010culprit lesions in acute syndromes were more often ruptured (OR\u00a0=\u00a02.25 (95% CI:1.05; 4.82), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037) or Thin\u2010Cap Fibroatheromas than in stable angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Culprit lesions from acute coronary patients are larger, more positively remodeled and contained more lipids as compared to stable angina lesions or non\u2010culprit in acute patients. Non culprit lesions are also more often complicated or vulnerable in acute than stable patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13671","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T18:57:08Z","timestamp":1629399428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intravascular ultrasound insights into the unstable features of the coronary atherosclerotic plaques: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Calin","family":"Homorodean","sequence":"first","affiliation":[{"name":"Internal Medicine Department Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"Emergency County Hospital Cluj Napoca  Cluj\u2010Napoca 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