{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:17:21Z","timestamp":1779214641478,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1.5.217.13N"],"award-info":[{"award-number":["1.5.217.13N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1.8.029.20N"],"award-info":[{"award-number":["1.8.029.20N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess whether tools to functionally examine the microcirculation, such as laser speckle contrast analysis (LASCA), are predictive of ischaemic digital trophic lesions ([i]DTL) in patients with systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, a systematic review (according to PRISMA) was conducted to identify studies describing a link between LASCA and SSc\u2010related (i)DTL. In the additional pilot study, consecutive SSc patients underwent clinical and LASCA examinations (to assess the peripheral blood perfusion [PBP] of both hands) at enrolment. For one year, a monthly telephone survey was conducted to investigate (i)DTL occurrence. Logistic regression and ROC analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the three manuscripts retained through the systematic review examined the predictive value of LASCA for future (i)DTL. In our pilot study, 7\/106 (6.6%) SSc patients developed at least one iDTL during follow\u2010up, with PBP not found to be predictive (OR\u00a0=\u00a00.995, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.418; ROC\u2013AUC\u00a0=\u00a00.597). Post hoc, when only patients not taking vasodilators were analysed (<jats:italic>n<\/jats:italic>\u00a0=\u00a057), all three who developed iDTL had an average PBP\u00a0\u2264\u00a070 PU, while only 9\/54 (16.7%) patients without iDTL occurrence had such values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A predictive role of LASCA for (i)DTL has not yet been described in the literature and could also not be attested by our additional pilot study, due to a lower\u2010than\u2010expected iDTL incidence in our day\u2010to\u2010day SSc population in which patients were allowed to continue their vasodilator medication. However, the promising observations in the subgroup of vasodilator\u2010na\u00efve patients encourage further investigation of this potential added value of LASCA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13672","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T14:40:56Z","timestamp":1629729656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictive value of laser speckle contrast analysis in systemic sclerosis. 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-7945","authenticated-orcid":false,"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ghent University Ghent Belgium"},{"name":"Department of Rheumatology Ghent University Hospital Ghent Belgium"},{"name":"Unit for Molecular Immunology and Inflammation VIB Inflammation Research Center Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The EULAR Study Group on Microcirculation in Rheumatic 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