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Nowadays, H<jats:sub>2<\/jats:sub>S is recognized as the third mammalian gasotransmitter, playing an important role in inflammation, septic shock, ischaemia reperfusion events, cardiovascular disease and more recently in liver physiology and chronic liver diseases such as non\u2010alcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This narrative review is based on literature search using PubMed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a bioenergetic perspective, H<jats:sub>2<\/jats:sub>S is a very unique molecule, serving as a mitochondrial poison at high concentrations or as an inorganic mitochondrial substrate at low concentrations. By using transgenic animal models to specifically modulate liver H<jats:sub>2<\/jats:sub>S biosynthesis or exogenous compounds that release H<jats:sub>2<\/jats:sub>S, several studies demonstrated that H<jats:sub>2<\/jats:sub>S is a key player in liver glucose and lipid metabolism. Liver H<jats:sub>2<\/jats:sub>S content and biosynthesis were also altered in NAFLD animal models with the in vivo administration of H<jats:sub>2<\/jats:sub>S\u2010releasing molecules preventing the further escalation into non\u2010alcoholic\u2010steatohepatitis. Liver steady\u2010state levels of H<jats:sub>2<\/jats:sub>S, and hence its cell signalling properties, are controlled by a tight balance between its biosynthesis, mainly through the transsulphuration pathway, and its mitochondrial oxidation via the sulphide oxidizing unit. However, studies investigating mitochondrial H<jats:sub>2<\/jats:sub>S oxidation in liver dysfunction still remain scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since H<jats:sub>2<\/jats:sub>S emerges as a key regulator of liver metabolism and metabolic flexibility, further understanding the physiological relevance of mitochondrial H<jats:sub>2<\/jats:sub>S oxidation in liver energy homeostasis and its potential implication in chronic liver diseases are of great interest.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13680","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T07:45:59Z","timestamp":1631605559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hydrogen sulphide in liver glucose\/lipid metabolism and non\u2010alcoholic fatty liver 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