{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:37:31Z","timestamp":1762522651742,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005884","name":"Centro Nacional de Investigaciones Cardiovasculares","doi-asserted-by":"publisher","award":["RD12\/0005,RD16\/0007"],"award-info":[{"award-number":["RD12\/0005,RD16\/0007"]}],"id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this work was to analyse the association of the retinal arteriolar calibre and the arteriole\/venule index (AV index) with vascular ageing in a general population without previous cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Descriptive cross\u2010sectional study. A total of 482 individuals without cardiovascular disease (mean age: 55.6\u00a0\u00b1\u00a014.2\u00a0years) were selected by random sampling, stratified by age and sex. The retinal arteriolar calibre was measured using digital fundus images of the back of the eye captured with a validated, semiautomatized and computer\u2010assisted software (Index calculator). Vascular ageing was defined using three criteria based on the values of: (1) Carotid\u2010femoral Pulse Wave Velocity (cfPWV), (2) Brachial\u2010ankle Pulse Wave Velocity (baPWV) and (3) Carotid Intima\u2010Media Thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AV index and arteriolar calibre show a negative correlation with age, arterial pressure, cardiovascular risk and parameters of vascular structure and function (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 in all cases). We found lower mean values of the AV index and arteriolar calibre in the individuals with early vascular ageing compared to those with healthy vascular ageing. AV index was negatively correlated with cfPWV ((\u03b2=\u22122.9; 95% CI (\u22124.7; \u22121.1)), baPWV ((\u03b2=\u22123.2; 95% CI (\u22125.4; \u22120.9)) and vascular ageing index ((\u03b2=\u22121.7; 95% CI (\u22122.7; \u22120.7)). Arteriolar calibre showed a negative correlation with baPWV (\u03b2=\u22120.1; 95% CI (\u22120.2; \u22120.1)). In the logistic regression analysis, lower values of AV index ((OR=0.01; 95% CI (0.01\u20130.10), OR=0.03; 95% CI (0.01\u20130.11) and OR=0.09; 95% CI (0.01\u20130.67)) were associated with EVA defined with cfPWV, baPWV and vascular ageing index respectively, and lower values of arteriolar calibre ((OR=0.71; 95% CI (0.55\u20130.91)) were associated with EVA defined with vascular ageing index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower values of AV index and retinal arteriolar calibre were associated with vascular ageing in a general Spanish population without previous cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13684","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T20:34:15Z","timestamp":1632861255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retinal blood vessel calibre and vascular ageing in a general Spanish population: A EVA study"],"prefix":"10.1111","volume":"52","author":[{"given":"Leticia","family":"G\u00f3mez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"G\u00f3mez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Patino\u2010Alonso","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Espa\u00f1a"},{"name":"Departamento de Estad\u00edstica Universidad de Salamanca Calle Alfonso X el Sabio s\/n Salamanca Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose I.","family":"Recio\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Espa\u00f1a"},{"name":"Departamento de Enfermer\u00eda y Fisioterapia Universidad de Salamanca Calle Donantes de Sangre, s\/n Salamanca Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Gonz\u00e1lez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL) Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Espa\u00f1a"},{"name":"Departamento de Enfermer\u00eda y Fisioterapia Universidad 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