{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:02:29Z","timestamp":1789246949390,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sudden restoration of normothermic conditions upon reperfusion of cold\u2010stored grafts has been suggested to entail a massive energy demand not yet met by the cells that still suffer from hypothermic torpor. An adapted and gentle rise of graft temperature by ex\u2010vivo machine perfusion has, therefore, been proposed. This should now be tested in the clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a first clinical series, six ECD\u2010kidneys were subjected to controlled oxygenated rewarming (COR) during short term pre\u2010implantation machine perfusion. Matched kidneys that were conventionally kept on ice served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early allograft function after transplantation was significantly improved by COR. On post\u2010operative day 7, clearance of creatinine was more than twofold higher after COR and fractional excretion of sodium in the normal range, while significantly elevated in control kidneys. Good correlations were seen between ulterior graft function and real\u2010time parameters obtained during pre\u2010transplant machine perfusion (Lactate: <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.9; TIMP2: <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.74). Conventional denominators of graft viability like kidney donor risk index KDRI were far less predictive (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is concluded that COR can be safely applied to renal grafts and appears to be a valuable tool to predict and improve early renal function after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13691","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T10:16:46Z","timestamp":1636366606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study"],"prefix":"10.1111","volume":"52","author":[{"given":"Hristo","family":"Zlatev","sequence":"first","affiliation":[{"name":"Surgical Research Department Essen Germany"},{"name":"Clinic for General, Visceral and Transplantation Surgery University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"von Horn","sequence":"additional","affiliation":[{"name":"Surgical Research Department Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Kaths","sequence":"additional","affiliation":[{"name":"Clinic for General, Visceral and Transplantation Surgery University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Paul","sequence":"additional","affiliation":[{"name":"Clinic for General, Visceral and Transplantation Surgery University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-3590","authenticated-orcid":false,"given":"Thomas","family":"Minor","sequence":"additional","affiliation":[{"name":"Surgical Research Department Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.06.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092059"},{"key":"e_1_2_9_4_1","first-page":"1921","article-title":"Improved approach for normothermic machine perfusion of cold stored kidney grafts","volume":"10","author":"Horn C","year":"2018","journal-title":"Am J Transl Res"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15647"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13403"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn158"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac620b"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.3.s4.11.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn667"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14154-w"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360501"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12235"},{"key":"e_1_2_9_15_1","article-title":"Controlled oxygenated rewarming compensates for cold storage\u2010induced dysfunction in kidney grafts","author":"Horn C","year":"2021","journal-title":"Transplantation"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12503"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:30:42Z","timestamp":1692847842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/eci.13691"],"URL":"https:\/\/doi.org\/10.1111\/eci.13691","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,8]]},"assertion":[{"value":"2021-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13691"}}