{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:09:10Z","timestamp":1779358150185,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The systemic immune\u2010inflammation index (SII) has been reported to have prognostic ability in various cardiovascular diseases; however, it has not been studied in type\u2010B aortic dissection (TBAD). We aimed to explore the relation of SII with short\u2010term and long\u2010term outcomes in TBAD patients undergoing thoracic endovascular repair (TEVAR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of a prospectively maintained database from 2010 to 2017. The patients were divided into two groups (high SII and low SII) as per the optimal cut\u2010off value determined using the receiver operating characteristic curve. Multivariate logistic and Cox regression analyses were performed to analyse the relationship between the SII and the short\u2010term and long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 805\u00a0TBAD patients who underwent TEVAR were enrolled. Twenty\u2010six (3.2%) patients died during hospitalisation. At the end of a median follow\u2010up duration of 48.80\u00a0mon, 70 (9.8%) patients had died. The patients were divided into the high\u2010SII group [<jats:italic>n<\/jats:italic>\u00a0=\u00a0333 (41.4%%)] and the low\u2010SII group [<jats:italic>n<\/jats:italic>\u00a0=\u00a0472 (58.6%)] as per the optimal cut\u2010off value of 1,062. Multivariable logistic analyses showed that a high\u2010SII score was independently associated with major adverse cardiovascular events (MACEs) in\u2010hospital (odd ratio [OR], 1.67; 95% confidence interval [CI], 1.13\u20132.47; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). In addition, multivariable Cox analyses showed that a high\u2010SII score could be an independent indicator for follow\u2010up adverse events (hazard ratio [HR], 1.70; 95% CI, 1.14\u20132.56, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic immune\u2010inflammation index is associated with both in\u2010hospital and long\u2010term outcomes in patients with TBAD undergoing TEVAR. Therefore, SII may serve as valuable tool for risk stratification before intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13692","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T16:44:10Z","timestamp":1635180250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Systemic immune\u2010inflammation index predicted the clinical outcome in patients with type\u2010B aortic dissection undergoing thoracic endovascular repair"],"prefix":"10.1111","volume":"52","author":[{"given":"Sheng","family":"Su","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine Southern Medical University Guangzhou China"},{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 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