{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:08Z","timestamp":1792226528068,"version":"4.4.0"},"reference-count":140,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["722619"],"award-info":[{"award-number":["722619"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["734719"],"award-info":[{"award-number":["734719"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of non\u2010alcoholic fatty liver disease (NAFLD) is now 25% in the general population but increases to more than 55% in subjects with obesity and\/or type 2 diabetes. Simple steatosis (NAFL) can develop into more severe forms, that is non\u2010alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma leading to death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this narrative review, we have discussed the current knowledge in the pathophysiology of fatty liver disease, including both metabolic and non\u2010metabolic factors, insulin resistance, mitochondrial function, as well as the markers of liver damage, giving attention to the alterations in lipid metabolism and production of lipotoxic lipids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Insulin resistance, particularly in the adipose tissue, is the main driver of NAFLD due to the excess release of fatty acids. Lipidome analyses have shown that several lipids, including DAGs and ceramides, and especially if they contain saturated lipids, act as bioactive compounds, toxic to the cells. Lipids can also affect mitochondrial function. Not only lipids, but also amino acid metabolism is impaired in NAFL\/NASH, and some amino acids, as branched\u2010chain and aromatic amino acids, glutamate, serine and glycine, have been linked to impaired metabolism, insulin resistance and severity of NAFLD and serine is a precursor of ceramides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The measurement of lipotoxic species and adipose tissue dysfunction can help to identify individuals at risk of progression to NASH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13695","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T17:03:12Z","timestamp":1635181392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non\u2010alcoholic steatohepatitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-8750","authenticated-orcid":false,"given":"Sara","family":"Guerra","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology (IFC) National Research Council (CNR) Pisa Italy"},{"name":"Sant'Anna School of Advanced Studies Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-0909","authenticated-orcid":false,"given":"Gabriele","family":"Mocciaro","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology (IFC) National Research Council (CNR) Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-1651","authenticated-orcid":false,"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology (IFC) National Research Council (CNR) Pisa Italy"},{"name":"Sant'Anna School of Advanced Studies Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312238"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2017.09.527"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108072"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322572"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31420"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.07.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.257"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5309"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0850-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0212-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05024-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.033"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0279"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.012369"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.039"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2157-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080306"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020555"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1807"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102658"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132158"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24793"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3855"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15738"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.034"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30664"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.012"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14556"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25539"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134165"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1682-x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.031"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28985"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170261"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.068"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.021"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.049"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20781"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0071"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89444"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.04.004"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.09.013"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.06.007"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3722"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M052977"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0025"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1318"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.002"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02304"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25739"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01584-12"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101084"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1167"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114142"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0001"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.08.002"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2008.03.003"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28287"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406499200"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.21.7794-7808.2003"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82204"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07725.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.11.004"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00492.2015"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M023382"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.05.039"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1147"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00033.2010"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76388"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12769"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031101"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1076"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25741"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23093"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.107599"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272105"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2017.08.015"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9100995"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.03.006"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.03.006"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1894-9"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29465"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13346"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr201223p"},{"issue":"3","key":"e_1_2_9_99_1","first-page":"E467","article-title":"Protein synthesis and breakdown in skin and muscle: a leg model of amino acid kinetics","volume":"267","author":"Biolo G","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.10.013"},{"issue":"2","key":"e_1_2_9_101_1","first-page":"E273","article-title":"Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity","volume":"270","author":"Luzi L","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.002"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2307"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.075184"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.5.362"},{"issue":"1","key":"e_1_2_9_106_1","first-page":"77","article-title":"The effect of normalization of plasma amino acids on hepatic encephalopathy in man","volume":"80","author":"Fischer JE","year":"1976","journal-title":"Surgery"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1549S"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246333"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20167422"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz2841"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108375"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0460"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.013"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.003"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.32"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P056002"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1282-2"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1439-8"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.08.014"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44442"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010883"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2981-2"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46658"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31391"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404027200"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220510"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31897"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14174"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050649"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.05.046"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.002"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23229"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr1002593"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2649-3"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw148"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307497"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.570628"},{"issue":"3","key":"e_1_2_9_140_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/eurheartj\/ehz387","article-title":"Development and validation of a ceramide\u2010 and phospholipid\u2010based cardiovascular risk estimation score for coronary artery disease patients","volume":"41","author":"Hilvo M","year":"2020","journal-title":"Eur Heart J"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170987"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13695","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T14:26:32Z","timestamp":1693146392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":140,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/eci.13695"],"URL":"https:\/\/doi.org\/10.1111\/eci.13695","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13695"}}