{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:19:13Z","timestamp":1772187553831,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of primary bile cholangitis (PBC) is linked to gut microbiota dysbiosis. This study investigated the association between the gut microbiome and elevated total bilirubin (TB) level in PBC patients treated with ursodeoxycholic acid (UCDA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 47\u00a0PBC patients with 12\u00a0months of UCDA treatment were enrolled. Patients were divided into the TB (+) (TB&gt;1\u00d7 upper limit of the normal range [ULN]; <jats:italic>n<\/jats:italic>\u00a0=\u00a020) and TB(\u2212) (TB\u22641\u00d7 ULN; <jats:italic>n<\/jats:italic>\u00a0=\u00a027) groups. Stool and serum specimens were collected, and microbiota composition and functional characteristics in the 2\u00a0groups were evaluated by 16S RNA gene sequencing and bioinformatic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bacterial diversity was lower in the TB(+) group than in the TB(\u2212) group, although there was no significant difference in bacterial community profile. The phylum Saccharibacteria showed differential abundance in the 2\u00a0groups. Meanwhile, the TB(\u2212) group had lower abundance of the <jats:italic>Gemmiger<\/jats:italic>, <jats:italic>Blautia<\/jats:italic>, <jats:italic>Anaerostipes<\/jats:italic> and <jats:italic>Coprococcus<\/jats:italic> genera than the TB(+) group, whereas <jats:italic>Holdemania<\/jats:italic> was absent. The abundance of <jats:italic>Gemmiger formicillis<\/jats:italic> and <jats:italic>Coprococcus eutactus<\/jats:italic> was positively correlated with that of <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>, while <jats:italic>Blautia<\/jats:italic>, <jats:italic>Anaerostipes<\/jats:italic> and <jats:italic>Coprococcus<\/jats:italic> were negatively correlated with total bile acid level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TB level in PBC patients treated for 12\u00a0months with UCDA is associated with a distinct gut microbiome profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13714","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:21:15Z","timestamp":1637421675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Alterations in gut microbiota and elevated serum bilirubin in primary biliary cholangitis patients treated with ursodeoxycholic acid"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-6649","authenticated-orcid":false,"given":"Weijia","family":"Han","sequence":"first","affiliation":[{"name":"Department of Liver Disease Center Shenzhen Hospital Southern Medical University Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Second Department of liver disease center Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Liver Disease Center Shenzhen Hospital Southern Medical University Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhui","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Liver Disease Center Shenzhen Hospital Southern Medical 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