{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:05Z","timestamp":1753878605607,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870983"],"award-info":[{"award-number":["81870983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To observe the expression of N\u2010methyl\u2010D\u2010aspartate (NMDA), apoptosis and the effect on neurological function recovery in rat model with middle cerebral artery occlusion (MCAO). Diffusion kurtosis imaging (DKI) was used to evaluate crossed cerebellar diaschisis (CCD) and to provide experimental and theoretical basis for the clinical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The MCAO models were established in rats. Eighty\u2010four rats were randomly and evenly divided into 7\u00a0groups, including control group, 6\u2010h group, 12\u2010h group, 24\u2010h group, 48\u2010h group, 7\u2010day group and 14\u2010day group. The rats were scanned by MRI at the above time points. Then, rats were sacrificed for H&amp;E staining, immunohistochemical staining and TUNEL staining to detect the expression of NMDA in the core infarct area and cerebellum. At the end, the discussion of relationships between molecular biology and MRI parameters (ADC derived from DWI, and MD, MK and FA derived from DKI) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The values of MD, ADC and FA in MCAO rats were all lower than those in the control group. All MRI parameters of the contralateral cerebellum were lower than those of the ipsilateral cerebellum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The parameters reached the lowest value at 12\u00a0h, except that the MK reached the highest at 12\u00a0h. The expression of NMDA showed a fluctuation along time in the MCAO group. Overall, it is higher in the MCAO group than in the control group, reaching the maximum at 24\u00a0h (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). At the same time, the expression of NMDA in the contralateral cerebellum was higher than in the ipsilateral cerebellum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is found that NMDA and DKI of CCD have the same changing trend, which indicates that the intervention of NMDA receptor apoptosis may become a new target for the treatment of cerebral infarction, and MRI parameters can predict the occurrence and development of CCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13716","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:25:23Z","timestamp":1638311123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of crossed cerebellar diaschisis after cerebral infarction in MCAO rats based on 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