{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:53:26Z","timestamp":1779119606104,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the distribution of circulating immune cell subsets in peripheral blood of patients with sarcoidosis and investigate if there is an association with an underlying cardiac involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eighty\u2010five newly diagnosed treatment\u2010na\u00efve patients with sarcoidosis (50 women) were included in the study. All patients underwent a thorough cardiac investigation, including cardiac magnetic resonance imaging (CMR). Of all patients, 19 (23.53%) had myocardial involvement, and the NK subpopulation in these patients in peripheral blood was significantly decreased compared to patients without (n\u00a0=\u00a063, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003 respectively). The absolute number of NKT cells (CD3+CD16\/56<jats:sup>+<\/jats:sup>) in patients with cardiac involvement was highly correlated with T2\u00a0map increased values in MRI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212686, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041) showing that low NKT cell count correlates with the inflammatory process of the heart. No difference in CD19, CD3, CD4, CD8 and CD3<jats:sup>\u2212<\/jats:sup>NK cell counts was found between groups. Lung severity was not found to correlate with the number of NK cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that low NK cell count in peripheral blood of patients with sarcoidosis is associated with cardiac involvement, and the number of NK\u2010T cells correlates with CMR findings indicative of myocardial inflammation. This finding might have a potential clinical application in detecting clinically silent cardiac involvement in sarcoidosis and may also suggest potential targets for therapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13742","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T12:39:05Z","timestamp":1642423145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral blood natural killer cells in sarcoidosis are associated with early cardiac involvement"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-7216","authenticated-orcid":false,"given":"Aigli G.","family":"Vakrakou","sequence":"first","affiliation":[{"name":"Neuroimmunology Laboratory 1st Department of Neurology School of Medicine Eginition Hospital, National and Kapodistrian University of Athens  Athens Greece"},{"name":"Immunology and Histocompatibility Department Evangelismos Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lykourgos","family":"Kolilekas","sequence":"additional","affiliation":[{"name":"7th Pulmonary Dept Athens Chest Hospital \"Sotiria\"  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Lama","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Medical Imaging 2nd Department of Radiology Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spiros","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical School General University Hospital \"Attikon\" National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigorios","family":"Stratakos","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Athens Chest Hospital \u2018Sotiria\u2019 Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Tsougos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Preventive Cardiology Section Ygeia Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effrosyni","family":"Manali","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Department Medical School General University Hospital \u2018Attikon\u2019 National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Grigoriou","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department Evangelismos Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherina","family":"Psarra","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department Evangelismos Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinos","family":"Kilidireas","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory 1st Department of Neurology School of Medicine Eginition Hospital, National and Kapodistrian University of Athens  Athens Greece"},{"name":"First Department of Neurology Medical School Aeginition Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spiros","family":"Papiris","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Department Medical School General University Hospital \u2018Attikon\u2019 National and Kapodistrian University of Athens  Athens 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