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It has been reported an association between some polymorphisms in the <jats:italic>diamine oxidase<\/jats:italic> (<jats:italic>DAO<\/jats:italic>) gene and migraine, especially in women. Two studies addressing DAO activity in migraine patients showed conflicting results. We investigated the possible relationship of serum DAO activity and histamine levels and 3 polymorphisms in the <jats:italic>DAO<\/jats:italic> gene with the risk for migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the frequencies of <jats:italic>DAO<\/jats:italic> rs10156191, rs1049742 and rs1049793\u00a0genotypes and allelic variants in 298\u00a0migraine patients and 360\u00a0healthy controls (using a <jats:italic>TaqMan<\/jats:italic>\u2010based qPCR assay), and serum DAO activity and histamine levels in a subset of 99\u00a0migraine patients and 115 controls with strict exclusion criteria, and analysed the relationship of these variables with several clinical features of migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of the <jats:italic>DAO<\/jats:italic> genotypes and allelic variants analysed were similar in migraine patients and controls. Serum DAO activity was significantly higher in migraine patients (Vmax\/Km 4.24\u00a0\u00b1\u00a02.93 vs. 3.60\u00a0\u00b1\u00a07.64, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), especially in females (Vmax\/Km 4.63\u00a0\u00b1\u00a02.96 vs. 3.18\u00a0\u00b1\u00a02.32, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), while serum histamine was similar in both study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum DAO activity was increased in patients with migraine, especially in females, while serum histamine levels were normal. None of the studied polymorphisms was associated with the risk for migraine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13757","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T14:52:12Z","timestamp":1643899932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased serum diamine oxidase activity in nonallergic patients with migraine"],"prefix":"10.1111","volume":"52","author":[{"given":"Elena","family":"Garc\u00eda\u2010Mart\u00edn","sequence":"first","affiliation":[{"name":"Universidad de Extremadura University Institute of Molecular Pathology Biomarkers  ARADyAL C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Navarro\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital La Mancha\u2010Centro  Alc\u00e1zar de San Juan (Ciudad Real) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Amo","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura University Institute of Molecular Pathology Biomarkers  ARADyAL C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura University Institute of Molecular Pathology Biomarkers  ARADyAL C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Serrador","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Hospital \u2018Pr\u00edncipe de Asturias\u2019 Universidad de Alcal\u00e1  Alcal\u00e1 de Henares (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Alonso\u2010Navarro","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario del Sureste  Arganda del Rey (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Calleja","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario del Sureste  Arganda del Rey (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Turp\u00edn\u2010Fenoll","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital La Mancha\u2010Centro  Alc\u00e1zar de San Juan (Ciudad Real) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Recio\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital La Mancha\u2010Centro  Alc\u00e1zar de San Juan (Ciudad Real) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Garc\u00eda\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital La Mancha\u2010Centro  Alc\u00e1zar de San Juan (Ciudad Real) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mill\u00e1n\u2010Pascual","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital La Mancha\u2010Centro  Alc\u00e1zar de San Juan (Ciudad Real) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Navacerrada","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario del Sureste  Arganda del Rey (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Plaza\u2010Nieto","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario del Sureste  Arganda del Rey (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Garc\u00eda\u2010Albea","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Neurology Hospital \u2018Pr\u00edncipe de Asturias\u2019 Universidad de Alcal\u00e1  Alcal\u00e1 de Henares (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura University Institute of Molecular Pathology Biomarkers  ARADyAL C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7323","authenticated-orcid":false,"given":"F\u00e9lix Javier","family":"Jim\u00e9nez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario del Sureste  Arganda del Rey (Madrid) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"MateosV ParejaJA PascualJ.Tratado de cefaleas. 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