{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:32:10Z","timestamp":1790281930395,"version":"4.1.0"},"reference-count":214,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["722619"],"award-info":[{"award-number":["722619"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide. Gut microbiota can play a role in the pathogenesis of NAFLD since dysbiosis is associated with reduced bacterial diversity, altered <jats:italic>Firmicutes<\/jats:italic>\/<jats:italic>Bacteroidetes<\/jats:italic> ratio, a relative abundance of alcohol\u2010producing bacteria, or other specific genera. Changes can promote disrupted intestinal barrier and hyperpermeability, filtration of bacterial products, activation of the immune system, and pro\u2010inflammatory changes in the intestine, in the liver, and at a systemic level. Microbiota\u2010derived molecules can contribute to the steatogenic effects. The link between gut dysbiosis and NAFLD, however, is confused by several factors which include age, BMI, comorbidities, dietary components, and lifestyle. The role of toxic chemicals in food and water requires further studies in both gut dysbiosis and NAFLD. We can anticipate that gut microbiota manipulation will represent a potential therapeutic tool to delay or reverse the progression of NAFLD, paving the way to primary prevention measures.<\/jats:p>","DOI":"10.1111\/eci.13768","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T16:49:41Z","timestamp":1647449381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The role of microbiota in nonalcoholic fatty liver disease"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-7376","authenticated-orcid":false,"given":"Agostino","family":"Di Ciaula","sequence":"first","affiliation":[{"name":"Clinica Medica \u201cA. Murri\u201d Department of Biomedical Sciences &amp; Human Oncology University of Bari Medical School  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonilde","family":"Bonfrate","sequence":"additional","affiliation":[{"name":"Clinica Medica \u201cA. Murri\u201d Department of Biomedical Sciences &amp; Human Oncology University of Bari Medical School  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-1471","authenticated-orcid":false,"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[{"name":"Clinica Medica \u201cA. Murri\u201d Department of Biomedical Sciences &amp; Human Oncology University of Bari Medical School  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082648"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020564"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.03.036"},{"issue":"22","key":"e_1_2_11_5_1","first-page":"5375","article-title":"Nonalcoholic fatty liver disease (NAFLD). mitochondria as players and targets of therapies?","volume":"2021","author":"Di Ciaula A","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123709"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3390"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010426"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.038"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04724.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws448"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31420"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00329.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07222.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12958"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.04.005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31150"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614362"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.03.021"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204265"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00064.2004"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.021"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.003"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10094-2"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30294-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30213-2"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0316-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.014"},{"key":"e_1_2_11_39_1","first-page":"434","article-title":"Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease","volume":"55","author":"Ludwig J","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290347"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04059.x"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1134"},{"issue":"124","key":"e_1_2_11_43_1","first-page":"e1","article-title":"Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is associated with nonalcoholic fatty liver disease","volume":"14","author":"Mittal S","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29085"},{"key":"e_1_2_11_45_1","first-page":"38","article-title":"Steatohepatitic hepatocellular carcinoma","volume":"7","author":"Torbenson MS","year":"2021","journal-title":"Hepatoma Research"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.014"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2017.08.003"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.3"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5367"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-IDDF.14"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020346"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324191"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.08.028"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006712"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93465"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31113"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1358525"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.009"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.053"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1433-4_12"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147702"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.12.004"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.31.100177.000543"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001397"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.013"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0111-5"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2710"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12489-0"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01908"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-018-7565-x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13145"},{"key":"e_1_2_11_73_1","article-title":"Gut microbiome dysbiosis and endotoxemia \u2010 Additional pathophysiological explanation for increased COVID\u201019 severity in obesity","volume":"20","author":"Belancic A","year":"2020","journal-title":"Obes Med"},{"key":"e_1_2_11_74_1","first-page":"3461","article-title":"Dysbiosis of Gram\u2010negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney disease","volume":"18","author":"Salguero MV","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18846"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.5499"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.5493"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.003"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.21216"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8787"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.5501"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509592103"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310283"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.212159"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3384"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30643"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3776-8"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314307"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151829"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900257"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283600d46"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09922"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01963.x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CBTO.0000013341.73139.fc"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i20.3007"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.116673"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2007.07.011"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2203085"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091913"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102115"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.668532"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109400"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1604458"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1302154"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601056103"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.049"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8110326"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19076"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.07.010"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22204"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170428103848"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28572"},{"key":"e_1_2_11_113_1","article-title":"Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases","volume":"8","author":"Kim HN","year":"2019","journal-title":"J Clin Med"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19753-9"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15071"},{"issue":"868","key":"e_1_2_11_116_1","first-page":"e1","article-title":"Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease","volume":"11","author":"Raman M","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01440-w"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(17)60019-5"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13031013"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09987-8"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20535"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15487"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002140"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59535-w"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29892"},{"issue":"1054","key":"e_1_2_11_127_1","first-page":"e5","article-title":"Gut Microbiome\u2010based metagenomic signature for non\u2010invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease","volume":"25","author":"Loomba R","year":"2017","journal-title":"Cell Metab"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28356"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30036"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.020"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019574108"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0131-2"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119677"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439263"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223490"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18847"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12580"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301012"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.05.008"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103100"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.774"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1996.0013"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.14.1438"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800494"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02007-1"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.003"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108621"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01159"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.15"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.005"},{"issue":"733","key":"e_1_2_11_152_1","first-page":"e12","article-title":"Loss of junctional adhesion molecule a promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol","volume":"151","author":"Rahman K","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6672636"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108383"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319290011"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00024.2006"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012191"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.057331"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/560620"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.81"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204772"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2019.05.006"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo4041101"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.027847"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14453"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020175"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01052-7"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00237"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP360"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170518095736"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114880"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115738"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017129117"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0218-2"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.10.387"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.03.011"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112515"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129004"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c00273"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50048"},{"key":"e_1_2_11_182_1","first-page":"1090","article-title":"Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial","volume":"15","author":"Aller R","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063388"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12758"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101725"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800930"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.03.017"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.86611"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517000204"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43228-0"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.07.009"},{"issue":"913","key":"e_1_2_11_192_1","first-page":"e7","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze A","year":"2012","journal-title":"Gastroenterology"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000661"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014324"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx662"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1177\/1724600818812471"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.08.005"},{"issue":"1219","key":"e_1_2_11_198_1","first-page":"e6","article-title":"The MBOAT7\u2010TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent","volume":"150","author":"Mancina RM","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.038"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15738"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008629"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712191"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09455-9"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26319"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062885"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08096"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213692"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030820"},{"issue":"675","key":"e_1_2_11_209_1","first-page":"e7","article-title":"Fatty liver disease caused by high\u2010alcohol\u2010producing Klebsiella pneumoniae","volume":"30","author":"Yuan J","year":"2019","journal-title":"Cell Metab"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26093"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiu002"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa382"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001033"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519003064"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.007"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T23:30:30Z","timestamp":1692747030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,26]]},"references-count":214,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/eci.13768"],"URL":"https:\/\/doi.org\/10.1111\/eci.13768","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,26]]},"assertion":[{"value":"2021-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13768"}}